NDLI: Investigation on the Microcirculation Effect of Local Application of Natural Hirudin on Porcine Random Skin Flap Venous Congestion

Content Provider	Springer Nature Link
Author	Guo Qian, Yin Gang, Wang Zhi Yong, Sun
Copyright Year	2011
Abstract	Medicinal leech therapy is commonly used to treat venous congestion by local application to skin flaps, which are frequently employed in re-construction surgery. In the present study, we investigated the effect of natural hirudin, which was applied locally to treat the venous congestion, in random skin flaps in a Guangxi Bama miniature pig model. The congestive random skin flaps were divided into 3 groups: Group A (control group that was locally applied with saline), Group B (locally applied with 20ATU natural hirudin per each flap), Group C (locally applied with 40ATU natural hirudin per each flap). The microcirculatory changes were observed by measuring myeloperoxidase (MPO), malondialdehyde (MDA) and superoxide dismutase (SOD). The level of MPO, MDA and SOD activities in the tissue in hirudin-treated groups was significantly different compared with control group (P < 0.05), but there was no significant difference between group B and group C. At 12 days, as compared to the control group, flap survival rate in hirudin-treated groups was significantly different (P < 0.05), but there was no significant difference between the groups receiving two different doses of hirudin. Natural hirudin can improve microcirculation by inhibiting oxygen free radical damage and also improve flap survival time.
Starting Page	141
Ending Page	146
Page Count	6
File Format	PDF
ISSN	10859195
Journal	Cell Biochemistry and Biophysics
Volume Number	62
Issue Number	1
e-ISSN	15590283
Language	English
Publisher	Humana Press Inc
Publisher Date	2011-09-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Natural hirudin Random skin flap Vein congestion Malondialdehyde (MDA) Myeloperoxidase (MPO) Malondialdehyde (SOD) Biophysics and Biological Physics Cell Biology Biochemistry Pharmacology/Toxicology Biotechnology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Medicine Biochemistry Biophysics

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