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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yang, Jiyuan Luo, Hesheng Li, Yan Li, Junchuan Cai, Zhiqiang Su, Xiaoyan Dai, Danqing Du, Wei Chen, Tingxuan Chen, Ming |
| Copyright Year | 2011 |
| Abstract | Accurate assessment of human epidermal growth factor receptor (HER) 2 is essential for efficient selection of patients who may benefit from therapies targeting this surface receptor (e.g., trastuzumab). Intratumoral heterogeneity of HER2 expression may potentially contribute to inaccurate assessment of HER2 status. To clarify intratumoral heterogeneity of HER2 expression and its potential clinical impact on assessment of HER2 status, we analyzed 148 endoscopic biopsy specimens and 117 excisional tumor specimens collected from 148 patients with primary gastric cancer. Specifically, we assessed HER2 protein overexpression and gene amplification using, respectively, immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH). There were 28 IHC-positive cases and 25 FISH-positive cases among these 148 patients. Heterogeneous HER2 protein expression was demonstrated in 23 of 29 (79.3%) IHC-positive cases, while gene expression heterogeneity was found in 11 of 25 (44.0%) FISH-positive cases. Intratumoral heterogeneity was the main reason of discordant results between IHC and FISH or between endoscopic biopsy and excisional tumor specimens. The clinical significance and impact of intratumoral HER2 expression heterogeneity on treatment outcome in gastric cancer require further studies. |
| Starting Page | 221 |
| Ending Page | 228 |
| Page Count | 8 |
| File Format | |
| ISSN | 10859195 |
| Journal | Cell Biochemistry and Biophysics |
| Volume Number | 62 |
| Issue Number | 1 |
| e-ISSN | 15590283 |
| Language | English |
| Publisher | Humana Press Inc |
| Publisher Date | 2011-09-17 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Gastric cancer Human epidermal growth factor receptor 2 Fluorescence in situ hybridization Immunohistochemistry Intratumoral heterogeneity Biophysics and Biological Physics Cell Biology Biochemistry Pharmacology/Toxicology Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Biochemistry Biophysics |
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