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| Content Provider | Springer Nature Link |
|---|---|
| Author | Xu, Zhi Qiang Liang, Xiao Min Zhang, Yuan Feng Zhu, Chun Xia Jiang, Xiao Jiang |
| Copyright Year | 2011 |
| Abstract | In the present study, we tested the efficacy and safety of Huperzine A in treatment of mild to moderate vascular dementia (VaD). This was a randomized, double-blinded, placebo-controlled study with 78 patients with mild to moderate VaD. The participants were randomized to receive either vitamin C (100-mg bid) as placebo (n = 39) or Huperzine A (0.1-mg bid) (n = 39) for 12 consecutive weeks. The mini-mental state examination (MMSE), clinical dementia rating (CDR), and activities of daily living (ADL) scores were used for the assessment of cognition. The assessments were made prior to treatment, and 4, 8, and 12 weeks of the treatment. The adverse effects of the treatment were also recorded. After 12 weeks of treatment, the MMSE, CDR, and ADL scores significantly improved in the Huperzine A group (P < 0.01 for all comparisons), whereas the placebo group did not show any such improvement (P > 0.05 for all comparisons). No serious adverse events were recorded during the treatment. Conclusion: Huperzine A can significantly improve the cognitive function in patients with mild to moderate vascular dementia. Further, the medicament is safe. |
| Starting Page | 55 |
| Ending Page | 58 |
| Page Count | 4 |
| File Format | |
| ISSN | 10859195 |
| Journal | Cell Biochemistry and Biophysics |
| Volume Number | 62 |
| Issue Number | 1 |
| e-ISSN | 15590283 |
| Language | English |
| Publisher | Humana Press Inc |
| Publisher Date | 2011-08-11 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Huperzine A Vascular dementia Cognition Mini-mental state examination Clinical dementia rating Activities of daily living Biophysics and Biological Physics Cell Biology Biochemistry Pharmacology/Toxicology Biotechnology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Medicine Biochemistry Biophysics |
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