NDLI: Impact of Pycnogenol$^{®}$ on cardiac extracellular matrix remodeling induced by l-NAME administration to old mice

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Impact of Pycnogenol$^{®}$ on cardiac extracellular matrix remodeling induced by l-NAME administration to old mice

Content Provider	Springer Nature Link
Author	Zibadi, Sherma Yu, Qianli Rohdewald, Peter J. Larson, Douglas F. Watson, Ronald Ross
Copyright Year	2007
Abstract	Cardiac remodeling is a determinant of the clinical progression of heart failure and now slowing or reversing remodeling is considered as a potential therapeutic target in heart failure. Pycnogenol$^{®}$ has been reported to mediate a number of beneficial effects in the cardiovascular system but its effects on hemodynamic and functional cardiovascular changes following cardiac remodeling have not been elucidated. Therefore, we investigated the influence of Pycnogenol$^{®}$ supplementation (30 mg/kg) on left ventricular function and myocardial extracellular matrix composition in old C57BL/6N mice following induction of cardiac remodeling by chronic nitric oxide synthase blockade by N $^{G}$-nitro-l-arginine methyl ester (l-NAME) administration. l-NAME-treated mice demonstrated dilated cardiomyopathy at compensated state, associated with a significant increase of pro-matrix metalloproteinase (MMP)-9 gene expression and activity, a marked decrease in pro-collagen IIIα$_{1 }$gene expression, and a subsequent reduction in cardiac total and cross-linked collagen content. Upon supplementation with Pycnogenol$^{®}$ in l-NAME-exposed mice, cardiac gene expression patterns for pro-MMP-2, -9, and -13, and MMP-9 activity were significantly decreased, associated with a significant increase in cardiac tissue inhibitor of metalloproteinase (TIMP)-4 expression. These findings were coincided with a marked increase in myocardial total and cross-linked collagen content, compared with l-NAME-only-treated mice. Moreover, Pycnogenol$^{®}$ treatment was associated with reversal of l-NAME-induced alternations in hemodynamic parameters. These data indicate that Pycnogenol$^{®}$ can prevent adverse myocardial remodeling induced by l-NAME, through modulating TIMP and MMPs gene expression, MMPs activity, and further reduction in myocardial collagen degradation rate.
Starting Page	10
Ending Page	18
Page Count	9
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	7
Issue Number	1
e-ISSN	15590259
Language	English
Publisher	Humana Press Inc
Publisher Date	2007-04-20
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Cardiac function Extracellular matrix Collagen Cardiology Pharmacology/Toxicology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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