NDLI: Contrary microRNA Expression Pattern Between Fetal and Adult Cardiac Remodeling: Therapeutic Value for Heart Failure

Content Provider	Springer Nature Link
Author	Yan, Hualin Li, Yifei Wang, Chuan Zhang, Yi Liu, Cong Zhou, Kaiyu Hua, Yimin
Copyright Year	2016
Abstract	microRNAs (miRNAs) belong to a class of non-coding RNAs that regulate post-transcriptional gene expression during development and disease. Growing evidence indicates abundant miRNA expression changes and their important role in cardiac hypertrophy and failure. However, the role of miRNAs in fetal cardiac remodeling is little known. Here, we investigated the altered expression of fifteen miRNAs in rat fetal cardiac remodeling compared with adult cardiac remodeling. Among fifteen tested miRNAs, eleven and five miRNAs (miR-199a-5p, miR-214-3p, miR-155-3p, miR-155-5p and miR-499-5p) are significantly differentially expressed in fetal and adult cardiac remodeling, respectively. After comparison of miRNA expression in fetal and adult cardiac remodeling, we find that miRNA expression returns to the fetal level in adult cardiac failure and is activated in advance of the adult level in fetal failure. The current study highlights the contrary expression pattern between fetal and adult cardiac remodeling and that supports a novel potential therapeutic approach to treating heart failure.
Starting Page	267
Ending Page	276
Page Count	10
File Format	PDF
ISSN	15307905
Journal	Cardiovascular Toxicology
Volume Number	17
Issue Number	3
e-ISSN	15590259
Language	English
Publisher	Springer US
Publisher Date	2016-08-10
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	microRNA Fetal cardiac remodeling Cardiac remodeling Heart failure Metabolic remodeling Pharmacology/Toxicology Cardiology
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Toxicology Cardiology and Cardiovascular Medicine

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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