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| Content Provider | Springer Nature Link |
|---|---|
| Author | Jadeja, Ravirajsinh N. Thounaojam, Menaka C. Patel, Dipak K. Devkar, Ranjitsinh V. Ramachandran, A. V. |
| Copyright Year | 2010 |
| Abstract | The aim of the present study was to evaluate the efficacy of pre-supplementation with pomegranate (Punica granatum L.) juice (PJ) on heart weight, infarct size, plasma marker enzymes of cardiac damage, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants, cardiac ATPases and histopathology of isoproterenol (IP)-induced cardiac necrosis (CN) in rats. Rats treated with IP (85 mg/kg, s.c.) for 2 days at an interval of 24 h caused significant (P < 0.05) infarct in myocardium and increase in heart weight, lipid peroxidation (LPO), activity levels of Ca$^{+2}$ ATPase and plasma marker enzymes, while there was significant (P < 0.05) decrease in endogenous enzymatic and non-enzymatic antioxidants and Na$^{+}$-K$^{+}$ and Mg$^{+2}$ATPases. Pre-supplementation with PJ for 30 consecutive days and treated with IP on days 29th and 30th showed significantly (P < 0.05) lesser increase in heart weight, infarct size, plasma marker enzymes, lipid peroxidation, Ca$^{+2}$ ATPase and a significant protective effect in endogenous enzymatic and non-enzymatic antioxidants, Na$^{+}$-K$^{+}$ and Mg$^{+2}$ ATPases compared to IP alone treated group. Present study provides first scientific report on protective effect of supplementation of Pomegranate juice against IP-induced CN in rats. |
| Starting Page | 174 |
| Ending Page | 180 |
| Page Count | 7 |
| File Format | |
| ISSN | 15307905 |
| Journal | Cardiovascular Toxicology |
| Volume Number | 10 |
| Issue Number | 3 |
| e-ISSN | 15590259 |
| Language | English |
| Publisher | Humana Press Inc |
| Publisher Date | 2010-05-28 |
| Publisher Place | New York |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Punica granatum L Isoproterenol Cardiac necrosis Free radicals Oxidative stress Cardiology Pharmacology/Toxicology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Molecular Biology Toxicology Cardiology and Cardiovascular Medicine |
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