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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yakovlev, A. V. Koroleva, K. S. Valiullina, F. F. Khazipov, R. N. |
| Copyright Year | 2013 |
| Abstract | Resting membrane potential is a critical parameter determining tonic or bursting mode of the thalamic neurons. Previous studies using whole-cell recordings showed that immature ventroposteriomedial (VPM) and lateral geniculate thalamic neurons are strongly depolarized and have resting membrane potential near −50 mV. Yet, whole-cell recordings are associated with an introduction of the shunting conductance via the gigaseal that may lead to membrane depolarization in small neurons with high, in the gigaohm range, membrane resistance. Therefore, we have performed measurements of resting potential of VPM neurons in slices obtained from neonatal rats of postnatal days P2-P7 using cell-attached recordings of NMDA channels as voltage sensors. Because currents through the NMDA channels reverse near 0 mV, we assumed that the resting potential should equal the reversal potential of currents through NMDA channels in cell-attached recordings. Analysis of the current-voltage relationships of NMDA currents revealed that the resting potential in the immature VPM neurons is around −74 mV and that it does not change during the first postnatal week. This suggests that VPM neurons may operate in the bursting mode during the early postnatal period and support the oscillatory activity (spindle-like bursts) in the developing thalamocortical networks. |
| Starting Page | 207 |
| Ending Page | 212 |
| Page Count | 6 |
| File Format | |
| ISSN | 19907478 |
| Journal | Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology |
| Volume Number | 7 |
| Issue Number | 3 |
| e-ISSN | 19907494 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-08-15 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | membrane potential neuron patch-clamp ion channels NMDA thalamus Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Biophysics |
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