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| Content Provider | Springer Nature Link |
|---|---|
| Author | Brevv, V. V. Fedorova, N. V. Indenbom, A. V. |
| Copyright Year | 2013 |
| Abstract | Adsorption of viral matrix protein M1 on the self-assembled monolayer of carboxyhexadecanthiol molecules simulating the surface of the cell membrane was studied by surface plasmon resonance refractometry technique. It was shown that in the acidic medium (pH 4.0) the fraction of irreversibly adsorbed protein increases with time. The protein formed a monolayer on the surface in concentration range from 50 to 500 nM. It was found that the amount of the adsorbed protein increased more than 3 times in this range. An important observation is that even at the lowest concentrations of the protein its molecules totally occupied the entire surface of the substrate, and a further protein addition did not lead to its further adsorption. To explain this phenomena, it was suggested that the number of M1 bonds with the surface increases during the adsorption, which leads to spreading of the protein molecules. Apparently, this effect is caused by the intrinsic disorder of the C-domain of the protein. It is hypothesized that the disassembly of the protein-lipid envelope of the influenza virus in the acidic medium does not result from desorption of the M1, but it is caused by the weakening of protein-protein bonds. |
| Starting Page | 228 |
| Ending Page | 233 |
| Page Count | 6 |
| File Format | |
| ISSN | 19907478 |
| Journal | Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology |
| Volume Number | 7 |
| Issue Number | 3 |
| e-ISSN | 19907494 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-08-15 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | M1 protein adsorption of proteins influenza virus surface plasmon resonance Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Biophysics |
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