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| Content Provider | Springer Nature Link |
|---|---|
| Author | Romav, R. A. Churbav, G. D. Rogachevskaya, O. A. Kolesnikov, S. S. |
| Copyright Year | 2013 |
| Abstract | Taste cells of type I express the polymodal receptor CASR previously found in a heterologous system to recognize bitter denatonium as a ligand. Here we studied responsiveness of the type I cells to a variety of sapid compounds using Ca$^{2+}$ imaging. Taste cells were isolated from mouse CV papillae and loaded with Ca$^{2+}$ dye Fluo-4. Type I cells were identified by their spindle-like shape and strong responsiveness to bath ATP. It was found that among a number of bitter and sweet substances, solely dinatonium stimulated Ca$^{2+}$ signaling in type I cells. Denatonium responses were inhibited by the PLC inhibitior U73122 and calcilytic NSP-2143, the observations pointing out to the involvement of PLC-coupled receptors, most likely being CASR. Our overall findings indicate that denatonium can be recognized not only by primary chemosensory cells of type II but also by taste cells of type I. |
| Starting Page | 242 |
| Ending Page | 244 |
| Page Count | 3 |
| File Format | |
| ISSN | 19907478 |
| Journal | Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology |
| Volume Number | 7 |
| Issue Number | 3 |
| e-ISSN | 19907494 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2013-08-15 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Biochemistry Biophysics |
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