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| Content Provider | Springer Nature Link |
|---|---|
| Author | Patel, Suman Gaur, Rashmi Upadhyaya, Mohita Mathur, Archana Mathur, Ajay K. Bhakuni, Rajendra S. |
| Copyright Year | 2011 |
| Abstract | The biotransformation of β-artemether (1) by cell suspension cultures of Glycyrrhiza glabra and Lavandula officinalis is reported here for the first time. The major biotransformed product appeared as a grayish-blue color spot on thin-layer chromatography (TLC) with transparent crystal-like texture. Based on its infrared (IR) and $^{1}$H nuclear magnetic resonance (NMR) spectra, the product was characterized as a tetrahydrofuran (THF)–acetate derivative (2). The highest conversion efficiencies of 57 and 60% were obtained when 8–9-day-old cell suspensions of G. glabra and L. officinalis were respectively fed with 4–7 mg of compound 1 in 40 ml of medium per culture and the cells were harvested after 2–5 days of incubation. The addition of compound 1 at the beginning of the culture cycle caused severe growth depression in a dose-dependent manner, resulting in poor bioconversion efficiency of ~25% at 2–5 mg/culture dose only. |
| Starting Page | 646 |
| Ending Page | 650 |
| Page Count | 5 |
| File Format | |
| ISSN | 13403443 |
| Journal | Journal of Natural Medicines |
| Volume Number | 65 |
| Issue Number | 3-4 |
| e-ISSN | 18610293 |
| Language | English |
| Publisher | Springer Japan |
| Publisher Date | 2011-05-05 |
| Publisher Place | Japan |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Artemether Biotransformation Cell suspension culture Glycyrrhiza glabra Lavandula officinalis THF acetate derivative Complementary & Alternative Medicine Plant Sciences Pharmacy Pharmacology/Toxicology Medicinal Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science |
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