NDLI: Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes

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Journal of Natural Medicines : Volume 65, Issue 2, April 2011

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Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes

Content Provider	Springer Nature Link
Author	Choi, Sun Sil Cha, Byung Yoon Iida, Kagami Sato, Masako Lee, Young Sil Teruya, Toshiaki Yonezawa, Takayuki Nagai, Kazuo Woo, Je Tae
Copyright Year	2011
Abstract	Adipose tissue plays an essential role in energy homeostasis as a metabolic and endocrine organ. Accordingly, adipocytes are emerging as a major drug target for obesity and obesity-mediated metabolic syndrome. Dysfunction of enlarged adipocytes in obesity is involved in obesity-mediated metabolic syndrome. Adipocytokines, such as adiponectin released from small adipocytes, are able to prevent these disorders. In this study, we found that honokiol, an ingredient of Magnolia officinalis used in traditional Chinese and Japanese medicines, enhanced adipocyte differentiation in 3T3-L1 preadipocytes. Oil Red O staining showed that treatment with honokiol in the presence of insulin dose-dependently increased lipid accumulation in 3T3-L1 preadipoyctes although its activity was weak compared with rosiglitazone. During adipocyte differentiation, the expression of peroxisome proliferator-activated receptor γ2 (PPARγ2) mRNA and PPARγ target genes such as adipocyte protein 2 (aP2), adiponectin, and GLUT4 was induced by treatment with 10 μM honokiol. However, honokiol failed to show direct binding to the PPARγ ligand-binding domain in vitro. In preadipocytes, treatment with honokiol in the presence of insulin increased the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 protein and Akt protein, early insulin signaling pathways related to adipocyte differentiation, compared with insulin-only treatment. Taken together, our results suggest that honokiol promotes adipocyte differentiation through increased expression of PPARγ2 mRNA and potentiation of insulin signaling pathways such as the Ras/ERK1/2 and phosphoinositide-3-kinase (PI3K)/Akt signaling pathways.
Starting Page	424
Ending Page	430
Page Count	7
File Format	PDF
ISSN	13403443
Journal	Journal of Natural Medicines
Volume Number	65
Issue Number	3-4
e-ISSN	18610293
Language	English
Publisher	Springer Japan
Publisher Date	2011-02-16
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Honokiol Adipocyte differentiation ERK1/2 PI3K/Akt Complementary & Alternative Medicine Plant Sciences Pharmacy Pharmacology/Toxicology Medicinal Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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