NDLI: Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes

Content Provider	Springer Nature Link
Author	Bamba, Yoshiri Yun, Young Sook Kunugi, Akira Iue, Hideshi
Copyright Year	2011
Abstract	Curcuma species (Zingiberaceae) are used as both food and medicine in Asia. Ten sesquiterpenes (1–10) and two curcuminoids (11 and 12) were isolated from the rhizomes of Curcuma aromatica Salisb. and identified. The compounds were evaluated for their ability to inhibit cytochrome P450 (CYP). Among them, the sesquiterpene (4S,5S)-(+)-germacrone-4,5-epoxide (7) inhibited certain subtypes of CYP more potently than or at levels comparable to the curcuminoids curcumin (11) and demethoxycurcumin (12); 7 (IC$_{50}$ = 1.0 ± 0.2 μM) > 12 (IC$_{50}$ = 7.0 ± 1.7 μM) > 11 (IC$_{50}$ = 14.9 ± 1.4 μM) for CYP3A4 inhibition; 12 (IC$_{50}$ = 1.4 ± 0.2 μM) > 11 (IC$_{50}$ = 6.0 ± 1.4 μM) > 7 (IC$_{50}$ = 7.6 ± 2.5 μM) for CYP2C9 inhibition; and 7 (IC$_{50}$ = 33.2 ± 3.6 μM) = 12 (IC$_{50}$ = 34.0 ± 14.2 μM) > 11 (IC$_{50}$ > 100 μM) for CYP1A2 inhibition. These results suggest the possibility that Curcuma aromatica Salisb. may cause food–drug interactions via cytochrome P450 inhibition by sesquiterpene 7 and curcuminoids 11 and 12.
Starting Page	583
Ending Page	587
Page Count	5
File Format	PDF
ISSN	13403443
Journal	Journal of Natural Medicines
Volume Number	65
Issue Number	3-4
e-ISSN	18610293
Language	English
Publisher	Springer Japan
Publisher Date	2011-02-03
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Curcuma aromatica Zingiberaceae Cytochrome P450 (CYP) Sesquiterpene Curcuminoid Complementary & Alternative Medicine Plant Sciences Pharmacy Pharmacology/Toxicology Medicinal Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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