NDLI: Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines

Content Provider	Springer Nature Link
Author	Kai, Hisahiro Akamatsu, Ena Torii, Eri Kodama, Hiroko Yukizaki, Chizuko Sakakibara, Yoichi Suiko, Masahito Morishita, Kazuhiro Kataoka, Hiroaki Matsu, Koji
Copyright Year	2011
Abstract	Adult T-cell leukaemia (ATL) is caused by human T-cell leukaemia virus type I (HTLV-I) infection and is resistant to conventional chemotherapy. We evaluated the inhibitory effects of agricultural plants on the proliferation of seven ATL-related human leukaemia cells, using three ATL cell lines (ED, Su9T01 and S1T), two human T-cell lines transformed by HTLV-I infection (HUT-102 and MT-2) and two HTLV-I-negative human T-cell acute lymphoblastic leukaemia cell lines (Jurkat and MOLT-4). A total of 52 samples of 80% ethanol extracts obtained from 30 types of agricultural plants were examined. On the basis of IC$_{50}$ values, we selected samples with greater activity than genistein, which was used as a positive control. The highest inhibitory effect was observed with extracts from leaves of Vaccinium virgatum Aiton (blueberry) on four cell lines (ED, Su9T01, HUT-102 and Jurkat); seeds of Momordica charantia L. (bitter gourd) exhibited the second highest activity. The bitter gourd seeds suppressed the proliferation of three cell lines (Su9T01, HUT-102 and Jurkat). The extracts from edible parts of Ipomea batatas LAM. (sweet potato), edible parts of Colocasia esculenta (L.) Schott (taro), skin of taro and seeds of Prunus mume Sieb. et Zucc. (mume) showed markedly greater inhibitory effects on Su9T01 than genistein. These findings suggest that ATL-preventative bioactive compounds may exist in these agricultural plants, which are considered to be functional foods.
Starting Page	651
Ending Page	655
Page Count	5
File Format	PDF
ISSN	13403443
Journal	Journal of Natural Medicines
Volume Number	65
Issue Number	3-4
e-ISSN	18610293
Language	English
Publisher	Springer Japan
Publisher Date	2011-02-04
Publisher Place	Japan
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Screening Agricultural plants Adult T-cell leukaemia (ATL) Human T-lymphotropic virus type I (HTLV-I) Complementary & Alternative Medicine Plant Sciences Pharmacy Pharmacology/Toxicology Medicinal Chemistry
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

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