NDLI: Mitogen-activated protein kinases and tumor necrosis factor alpha responses of macrophages infected with Orientia tsutsugamushi

Content Provider	Springer Nature Link
Author	Yun, Ji Hyun Koo, Jung Eun Koh, Young Sang
Copyright Year	2009
Abstract	Orientia tsutsugamushi, an obligatory intracellular bacterium, is the causative agent of scrub typhus. The disease is histopathologically characterized by inflammatory manifestations, indicating that orientiae induce mechanisms that amplify the inflammatory response. Here we investigated the transcriptional response of tumor necrosis factor alpha (TNF-α) gene and the host cell responses of nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) to O. tsutsugamushi. Induction of the TNF-α gene was not blocked by a eukaryotic protein synthesis inhibitor cycloheximide, suggesting that de novo synthesis of host cell protein is not required for this transcriptional response. The induction of TNF-α mRNA by O. tsutsugamushi was not blocked by the inhibitors of NF-κB activation. Inactivation of Orientia by heat abolished both MAPK activation and TNF-α production, whereas treatment of host cells with cytochalasin D impaired neither NF-κB and MAPK activation nor TNF-α production. In conclusion, our data suggest that O. tsutsugamushi-stimulated TNF-α production and MAPK activation requires cellular attachment by viable orientiae but not bacterial internalization into the host cells.
Starting Page	2157
Ending Page	2164
Page Count	8
File Format	PDF
ISSN	09593993
Journal	World Journal of Microbiology and Biotechnology
Volume Number	25
Issue Number	12
e-ISSN	15730972
Language	English
Publisher	Springer Netherlands
Publisher Date	2009-07-16
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Orientia tsutsugamushi Mitogen-activated protein kinase Tumor necrosis factor alpha Nuclear factor-kappa B Microbiology Environmental Engineering/Biotechnology Applied Microbiology Biochemistry Biotechnology
Content Type	Text
Resource Type	Article
Subject	Physiology Medicine Applied Microbiology and Biotechnology Biotechnology

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