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Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hofer-Warbinek, Renate Stehlik, Christian Lipp, Joachim Martin, Rainer De |
| Copyright Year | 2000 |
| Abstract | Exposure of endothelial and many other cell types to tumor necrosis factor alpha generates both apoptotic and anti-apoptotic signals. The anti-apoptotic pathway leads to activation of the transcription factor NF-kappaB that regulates the expression of genes such as A20 or members of the IAP gene family that protect cells from tumor necrosis factor alpha-mediated apoptosis. In turn, some anti-apoptotic genes have been shown to modulate NF-kappaB activity. Here we demonstrate that XIAP, a NF-kappaB-dependent member of the IAP gene family, is a strong stimulator of NF-kappaB. Expression of XIAP leads to increased nuclear translocation of the p65 subunit of NF-kappaB via a novel signaling pathway that involves the mitogen-activated protein kinase kinase kinase TAK1. We show that TAK1 physically interacts with NIK and with IKK2, and both XIAP or active TAK1 can stimulate IKK2 kinase activity. Thus, XIAP may be part of a system of regulatory loops that balance a cell's response to environmental stimuli. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.stehliklab.org/assets/2000stehlik(xiap)jbc.pdf |
| PubMed reference number | 10807933v1 |
| Volume Number | 275 |
| Issue Number | 29 |
| Journal | The Journal of biological chemistry |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Apoptosis Endothelium Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta MAP3K7 wt Allele Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Mitogens NF-kappa B Neoplasms Nuclear Translocation Signal Transduction Pathways TRANSCRIPTION FACTOR XIAP gene cell type tumor necrosis |
| Content Type | Text |
| Resource Type | Article |
