NDLI: Mitogen-activated protein kinases are involved in tumor necrosis factor alpha production in macrophages infected withOrientia tsutsugamushi

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Mitogen-activated protein kinases are involved in tumor necrosis factor alpha production in macrophages infected withOrientia tsutsugamushi

Content Provider	Scilit
Author	Yun, Ji-Hyun Koo, Jung-Eun Koh, Young-Sang
Copyright Year	2009
Description	Journal: Microbiology and Immunology Orientia tsutsugamushi, an obligatory intracellular bacterium, is the causative agent of scrub typhus. Here the role of MAPK in TNF-alpha production in macrophages after infection with O. tsutsugamushi has been investigated. ERK1/2, JNK, and p38 MAPK became phosphorylated in Orientia-stimulated macrophages. Selective inhibitors of MAPK cascades could all significantly reduce Orientia-stimulated TNF-alpha production. Orientia-stimulated TNF-alpha production via p38 and JNK pathways was regulated by a post-transcriptional mechanism, whereas the ERK pathway mainly controlled the transcriptional step of TNF-alpha gene expression during infection. In conclusion, our data indicate that MAPK signaling is required to induce maximal TNF-alpha production in macrophages during Orientia infection.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1348-0421.2009.00127.x/pdf
Ending Page	355
Page Count	7
Starting Page	349
ISSN	03855600
e-ISSN	13480421
DOI	10.1111/j.1348-0421.2009.00127.x
Journal	Microbiology and Immunology
Issue Number	6
Volume Number	53
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-06-01
Access Restriction	Open
Subject Keyword	Journal: Microbiology and Immunology Mitogen‐activated Protein Kinase Orientia Tsutsugamushi Tumor Necrosis Factor Alpha
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology

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