NDLI: Activation of mitogen-activated protein kinases is involved in the induction of interferon β gene in macrophages infected withOrientia tsutsugamushi

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Activation of mitogen-activated protein kinases is involved in the induction of interferon β gene in macrophages infected withOrientia tsutsugamushi

Content Provider	Scilit
Author	Koo, Jung-Eun Yun, Ji-Hyun Lee, Keun-Hwa Hyun, Jin-Won Kang, Hee-Kyoung Jang, Won-Jong Park, Kyung-Hee Koh, Young-Sang
Copyright Year	2009
Description	Journal: Microbiology and Immunology We investigated the role of MAPK in IFN-beta gene expression in macrophages after infection with Orientia tsutsugamushi. ERK1/2 became phosphorylated in Orientia-stimulated macrophages. Selective inhibition of ERK1/2 and p38 MAPK could all significantly reduce Orientia-stimulated IFN-beta mRNA expression. Orientia inactivation by heat abolished IFN-beta mRNA induction only, whereas cytochalasin D treatment completely blocked both IFN-beta and chemokine expression, suggesting requirement of cellular internalization by viable bacteria for IFN-beta gene induction. In conclusion, our data indicate that MAPK pathways are required to induce maximal IFN-beta gene expression in macrophages during Orientia infection.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1348-0421.2008.00098.x/pdf
Ending Page	129
Page Count	7
Starting Page	123
ISSN	03855600
e-ISSN	13480421
DOI	10.1111/j.1348-0421.2008.00098.x
Journal	Microbiology and Immunology
Issue Number	2
Volume Number	53
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2009-02-01
Access Restriction	Open
Subject Keyword	Journal: Microbiology and Immunology Mitogen‐activated Protein Kinase Orientia Tsutsugamushi
Content Type	Text
Resource Type	Article
Subject	Virology Immunology Microbiology

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