NDLI: Detection of human enterovirus 71 and Coxsackievirus A16 in an outbreak of hand, foot, and mouth disease in Henan Province, China in 2009

Content Provider	Springer Nature Link
Author	Fan, Xingliang Jiang, Jun Liu, Yanjing Huang, Xueyong Wang, Pengzhi Liu, Licheng Wang, Junzhi Chen, Weijun Wu, Weili Xu, Bianli
Copyright Year	2012
Abstract	During 2009, an outbreak of hand, foot, and mouth disease (HFMD) enrolled 490 people in Henan Province, causing the death of two children. In order to investigate the pathogens responsible for this outbreak and characterize their genetic characteristics, a total of 508 clinical specimens (stool, throat swab, and vesicle fluid) were collected from the Center for Disease Control and Prevention of Henan Province. Virological investigations (virus isolation, conventional reverse transcription PCR, and real-time reverse transcription PCR) and phylogenetic analysis were performed. It was found that human enterovirus 71 (EV71) was the main pathogen causing this outbreak, while Coxsackievirus A16 (CoxA16) played only a subsidiary role. Phylogenetic analysis of 24 EV71 isolates collected during the period from March 11 to July 24, 2009 showed that they belonged to subgenotypes C4 and C5. Our study for the first time characterizes the epidemiology of HFMD and EV71 infection in Henan Province in 2009 and provides the first direct evidence of the genotype of EV71 circulating in Henan Province at that time. Our study should facilitate the development of public health measures for the control and prevention of HFMD and EV71 infection in at-risk individuals in China.
Starting Page	1
Ending Page	9
Page Count	9
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	46
Issue Number	1
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2012-10-19
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	HFMD EV71 Phylogenetic analysis VP1 gene Subgenotype C4 and C5 Medical Microbiology Virology Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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