NDLI: Hepatitis E virus from India exhibits significant amino acid mutations in fulminant hepatic failure patients

Content Provider	Springer Nature Link
Author	Mishra, Nischay Walimbe, Atul M. Arankalle, Vidya A.
Copyright Year	2012
Abstract	In India, hepatitis E virus (HEV) is the predominant cause of acute viral hepatitis (AVH) and fulminant hepatic failure (FHF) among pregnant women and adults. The present study evaluates association, if any, of the mutations in the viral genome with disease outcome. Ten genotype-1 complete genomes (five each from AVH and FHF patients) were sequenced. Phylogenetic analysis showed a distinct cluster including all five FHF–HEV sequences from western India (present study), one FHF isolate from northern India, and one AVH isolate detected in 2010 (present study). HEV genotype-1 sequences from fulminant cases exhibited 150 significantly different (p ≤ 0.05) nucleotide substitutions when compared to all genotype-1-AVH sequences as well as isolates from the Indian subcontinent. At six positions, all FHF sequences showed identical substitutions (1 non-synonymous). Six amino acid changes in ORF1; F179S, A317T, T735I, L1110F, V1120I, and F1439Y were significantly associated with HEV-type-1 FHF. The data suggests that the nucleotide substitutions recorded and/or L1110F and V1120I amino acid substitutions in helicase domain may play important role in determining outcome of HEV infection.
Starting Page	47
Ending Page	53
Page Count	7
File Format	PDF
ISSN	09208569
Journal	Virus Genes
Volume Number	46
Issue Number	1
e-ISSN	1572994X
Language	English
Publisher	Springer US
Publisher Date	2012-10-10
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hepatitis E virus Acute viral hepatitis Fulminant hepatic failure Complete genome sequencing Amino acid mutations Medical Microbiology Virology Plant Sciences
Content Type	Text
Resource Type	Article
Subject	Virology Genetics Medicine Molecular Biology

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