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| Content Provider | Springer Nature Link |
|---|---|
| Author | Yoshida, Sakiko Higuchi, Masaya Shoji, Toshiyuki Yoshita, Manami Ishioka, Kojiro Takahashi, Masahiko Oie, Masayasu Tanaka, Yuetsu Uchiyama, Makoto Fujii, Masahiro |
| Copyright Year | 2008 |
| Abstract | Human T-cell leukemia virus type 1 (HTLV-1) spreads through cell-to-cell contact by forming a virological synapse. Based on the finding that HTLV-1 envelope glycoprotein (Env) binds to a PDZ domain containing scaffold protein Dlg1, whose function has been implicated in the organization of neuronal and immunological synapses, we examined the role of Dlg1 in the cell-cell infection by HTLV-1. The coculture of an HTLV-1-infected T-cell line MT-2 with an uninfected MOLT-4 induced syncytium, a marker of cell-cell HTLV-1 infection, but an RNA interference-mediated knockdown of Dlg1 in both cells cooperatively reduced the syncytium formation. In HTLV-1-uninfected 293T cells, Dlg1 induced the clustering of GLUT1, a cellular receptor for HTLV-1, but such clustering was abrogated by a deletion of the PDZ domain binding motif of GLUT1 (GLUT1ΔC). GLUT1 expression in MDBK cells induced HTLV-1-mediated syncytium formation, and the activity was much greater than that of GLUT1ΔC. These results suggest that Dlg1, through the interaction with GLUT1 as well as Env, plays a positive role in the syncytium formation induced by HTLV-1. |
| Starting Page | 9 |
| Ending Page | 15 |
| Page Count | 7 |
| File Format | |
| ISSN | 09208569 |
| Journal | Virus Genes |
| Volume Number | 37 |
| Issue Number | 1 |
| e-ISSN | 1572994X |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2008-05-07 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Human T-cell leukemia virus type 1 Dlg Envelope Fusion Plant Sciences Virology Medical Microbiology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Virology Genetics Medicine Molecular Biology |
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