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Expression of glucose transporter 1 confers susceptibility to human T-cell leukemia virus envelope-mediated fusion.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Coskun, Ayse Kubra Sutton, Richard E. |
| Copyright Year | 2005 |
| Abstract | Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus identified and causes both adult T-cell leukemia/lymphoma and tropical spastic paraparesis/HTLV-1-associated myelopathy, among other disorders. In vitro, HTLV-1 has an extremely broad host cell tropism in that it is capable of infecting most mammalian cell types, although at the same time viral titers remain relatively low. Despite years of study, only recently has a bona fide candidate cellular receptor, glucose transporter 1 (glut-1), been identified. Although glut-1 was shown to bind specifically to the ectodomain of HTLV-1 and HTLV-2 envelope glycoproteins, which was reversible with small interfering RNA directed against glut-1, cellular susceptibility to HTLV upon expression of glut-1 was not established. Here we show that expression of glut-1 in relatively resistant MDBK cells conferred increased susceptibility to both HTLV-1- and HTLV-2-pseudotyped particles. glut-1 also markedly increased syncytium formation in MDBK cells after exposure to HTLV-1. Another assay also demonstrated HTLV-1 envelope-cell fusion in the presence of glut-1. Taken together, these results provide additional evidence that glut-1 is a receptor for HTLV. |
| Starting Page | 164 |
| Ending Page | 164 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jvi.asm.org/content/79/7/4150.full.pdf |
| PubMed reference number | 15767416v1 |
| Volume Number | 79 |
| Issue Number | 7 |
| Journal | Journal of virology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Giant Cells Glucose Transporter HIV Host Cell Human T-lymphotropic virus 1 Human T-lymphotropic virus 2 Leukemia, B-Cell Leukemia, T-Cell Lymphoma Mammals Paraparesis, Spastic RNA SLC2A1 gene Spinal Cord Diseases T-Cell Leukemia Viruses, Human T-Lymphocyte Tropical Spastic Paraparesis Tropism cell type polysaccharide-K syncytium formation |
| Content Type | Text |
| Resource Type | Article |
