NDLI: Effect of Resveratrol on Gliotransmitter Levels and p38 Activities in Cultured Astrocytes

Content Provider	Springer Nature Link
Author	Zhou, Hao Chen, Qing Kong, Dan Li Guo, Jiang Wang, Qian Yu, Shou Yi
Copyright Year	2010
Abstract	Accumulating evidence suggests that resveratrol may have beneficial effects against traumatic brain injury. However, its effect on the regulation of extracellular levels of gliotransmitter and on the activation of p38 MAPK in astrocytes is still unknown. We have examined whether resveratrol regulates extracellular levels of gliotransmitter as well as the activation of p38 MAPK in cultured astrocytes before and after stretch injury. The extracellular levels of glutamate, d-/l-serine and d-serine were apparently reduced by 100 μM resveratrol in control astrocyte cultures. The dramatic increase of glutamate and d-serine release induced by stretch injury was also clearly inhibited by resveratrol. Resveratrol mediates this response by reduction of release through inhibition of extracellular calcium influx and increment of gliotransmitter uptake through enhancement of amino acid transporter expressed in the membrane of astrocyte. In addition, resveratrol definitely reduced the activation of p38 MAPK in cultured astrocytes following stretch injury. AMPA receptor is involved in the activation of p38 following injury. Conversely, the levels of glutamine and glycine were not obviously affected by resveratrol before and after injury. Intracellular levels of glutamate and d-serine are not apparently changed by stretch injury. Collectively, our data suggest that resveratrol might play an important role in protection of the nervous system after injury by decreasing the extracellular levels of gliotransmitter and inhibiting activation of p38 MAPK following injury.
Starting Page	17
Ending Page	26
Page Count	10
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	36
Issue Number	1
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2010-09-15
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Resveratrol Amino acid p38 MAPK Astrocyte Stretch injury Neurology Cell Biology Biochemistry Neurochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Role of Astrocytes in Pain

Resveratrol Protects Hippocampal Astrocytes Against LPS-Induced Neurotoxicity Through HO-1, p38 and ERK Pathways

Is there In Vivo Evidence for Amino Acid Shuttles Carrying Ammonia from Neurons to Astrocytes?

Primary Cultures of Astrocytes: Their Value in Understanding Astrocytes in Health and Disease

Theophylline Potentiates Lipopolysaccharide-Induced NO Production in Cultured Astrocytes

Exocytosis in Astrocytes: Transmitter Release and Membrane Signal Regulation

Characterization of Amino Acid Profile and Enzymatic Activity in Adult Rat Astrocyte Cultures

Serum amyloid A inhibits astrocyte migration via activating p38 MAPK

Extracellular Superoxide Dismutase Induced by Dopamine in Cultured Astrocytes

Effect of Resveratrol on Gliotransmitter Levels and p38 Activities in Cultured Astrocytes

Similar Documents

Role of Astrocytes in Pain

Resveratrol Protects Hippocampal Astrocytes Against LPS-Induced Neurotoxicity Through HO-1, p38 and ERK Pathways

Is there In Vivo Evidence for Amino Acid Shuttles Carrying Ammonia from Neurons to Astrocytes?

Primary Cultures of Astrocytes: Their Value in Understanding Astrocytes in Health and Disease

Theophylline Potentiates Lipopolysaccharide-Induced NO Production in Cultured Astrocytes

Exocytosis in Astrocytes: Transmitter Release and Membrane Signal Regulation

Characterization of Amino Acid Profile and Enzymatic Activity in Adult Rat Astrocyte Cultures

Serum amyloid A inhibits astrocyte migration via activating p38 MAPK

Extracellular Superoxide Dismutase Induced by Dopamine in Cultured Astrocytes

Effect of Resveratrol on Gliotransmitter Levels and p38 Activities in Cultured Astrocytes