NDLI: RETRACTED ARTICLE: Anti-Inflammatory Effects of Chronic Aspirin on Brain Arachidonic Acid Metabolites

Content Provider	Springer Nature Link
Author	Basselin, Mireille Ramadan, Epolia Chen, Mei Rapoport, Stanley I.
Copyright Year	2010
Abstract	Pro-inflammatory and anti-inflammatory mediators derived from arachidonic acid (AA) modulate peripheral inflammation and its resolution. Aspirin (ASA) is a unique non-steroidal anti-inflammatory drug, which switches AA metabolism from prostaglandin E$_{2}$ (PGE$_{2}$) and thromboxane B$_{2}$ (TXB$_{2}$) to lipoxin A$_{4}$ (LXA$_{4}$) and 15-epi-LXA$_{4}$. However, it is unknown whether chronic therapeutic doses of ASA are anti-inflammatory in the brain. We hypothesized that ASA would dampen increases in brain concentrations of AA metabolites in a rat model of neuroinflammation, produced by a 6-day intracerebroventricular infusion of bacterial lipopolysaccharide (LPS). In rats infused with LPS (0.5 ng/h) and given ASA-free water to drink, concentrations in high-energy microwaved brain of PGE$_{2}$, TXB$_{2}$ and leukotriene B$_{4}$ (LTB$_{4}$) were elevated. In rats infused with artificial cerebrospinal fluid, 6 weeks of treatment with a low (10 mg/kg/day) or high (100 mg/kg/day) ASA dose in drinking water decreased brain PGE$_{2}$, but increased LTB$_{4}$, LXA$_{4}$ and 15-epi-LXA$_{4}$ concentrations. Both doses attenuated the LPS effects on PGE$_{2}$, and TXB$_{2}$. The increments in LXA$_{4}$ and 15-epi-LXA$_{4}$ caused by high-dose ASA were significantly greater in LPS-infused rats. The ability of ASA to increase anti-inflammatory LXA$_{4}$ and 15-epi-LXA$_{4}$ and reduce pro-inflammatory PGE$_{2}$ and TXB$_{2}$ suggests considering aspirin further for treating clinical neuroinflammation.
Starting Page	139
Ending Page	145
Page Count	7
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	36
Issue Number	1
e-ISSN	15736903
Language	English
Publisher	Springer New York
Publisher Date	2010-10-28
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Aspirin Neuroinflammation Eicosanoids Arachidonic acid Lipoxin A$_{4}$ 15-epi-lipoxin A$_{4}$ Neurosciences Neurochemistry Biochemistry Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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Retraction Note to: Anti-Inflammatory Effects of Chronic Aspirin on Brain Arachidonic Acid Metabolites

Retraction Note to: Anti-Inflammatory Effects of Chronic Aspirin on Brain Arachidonic Acid Metabolites

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RETRACTED ARTICLE: Anti-Inflammatory Effects of Chronic Aspirin on Brain Arachidonic Acid Metabolites

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RETRACTED ARTICLE: Anti-Inflammatory Effects of Chronic Aspirin on Brain Arachidonic Acid Metabolites