NDLI: Salvianolic Acid A Exerts Antiamnesic Effect on Diazepam-Induced Anterograde Amnesia in Mice

Content Provider	Springer Nature Link
Author	Wang, T. Shan, S. Y. Han, B. Zhang, L. M. Fu, F. H.
Copyright Year	2010
Abstract	Benzodiazepine was known to produce amnesia. Salvianolic acid A extracted from Salvia miltiorrhiza was an effective antioxidant. The objective of the study was to evaluate the effect of salvianolic acid A on diazepam-induced amnesia in mice. C57BL/6 mice were treated with salvianolic acid A at doses of 10, 20 and 40 mg/kg following administration with diazepam at a dose of 3 mg/kg. Morris water maze was performed to evaluate the effect of salvianolic acid A on amnesia. The antioxidative parameters in hippocampus were measured. The results showed that salvianolic acid A decreased the mean escape latency and increased the percentage of time spent in target quadrant. Salvianolic acid A reduced the content of malondialdehyde and increased the activities of superoxide dismutase, catalase and glutathione peroxidase in hippocampus. The findings demonstrated that salvianolic acid A had antiamnesic effects on diazepam-induced anterograde amnesia in mice, by augmenting the antioxidative capacity of hippocampus.
Starting Page	103
Ending Page	108
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	36
Issue Number	1
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2010-09-30
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Salvianolic acid A Diazepam Amnesia Hippocampus Antioxidant Neurology Cell Biology Biochemistry Neurochemistry Neurosciences
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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