NDLI: The Dose-Dependent Antioxidant Effects of Physical Exercise in the Hippocampus of Mice

Content Provider	Springer Nature Link
Author	Speck, Ana Elisa Tromm, Camila Baumer Pozzi, Bruna Gianatassio Paganini, Carla Souza Tuon, Talita Silveira, Paulo C. L. Aguiar, Aderbal Silva Pinho, Ricardo Auri
Copyright Year	2014
Abstract	Exercise increases both the consumption of oxygen and the production of reactive species in biological tissues, and this is counterbalanced by antioxidant adaptations to regular physical training. When the intensity of exercise fluctuates between mild and moderate, it improves the status of reduction–oxidation balance in the brain and induces neuroplasticity. However, intense exercise can oxidize the brain and impair neurological function. The effect of the frequency of exercise, which is an important factor in physical training, is still unknown. The effect of periodic exercise on biomarkers of oxidative stress in the hippocampus of mice was evaluated in this study. Mice were made to run on a treadmill for 8 weeks, two, three, or five times per week, and their hippocampi and quadriceps femoris muscles were then dissected. Biomarkers of oxidative damage were negatively correlated with the frequency of exercise and mitochondrial muscular activity, while the sulfhydryl contents were positively correlated with exercise frequency. A logistic analysis revealed a dose-dependent effect of exercise on these biomarkers. In summary, these results suggested that manipulating the frequency of physical exercise could induce antioxidant-related adaptations in the hippocampi of adult mice.
Starting Page	1496
Ending Page	1501
Page Count	6
File Format	PDF
ISSN	03643190
Journal	Neurochemical Research
Volume Number	39
Issue Number	8
e-ISSN	15736903
Language	English
Publisher	Springer US
Publisher Date	2014-05-25
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Exercise Oxidative stress Hippocampus Oxidative damage Neurosciences Neurochemistry Biochemistry Cell Biology Neurology
Content Type	Text
Resource Type	Article
Subject	Medicine Biochemistry Cellular and Molecular Neuroscience

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