NDLI: Effects of Selective 5-HT$_{1A}$ Receptor Ligands on Impulsive and Self-Controlled Behavior in Rats

Content Provider	Springer Nature Link
Author	Zaichenko, M. I. Merzhava, G. Kh. Vanetsian, G. L.
Copyright Year	2013
Abstract	The effects of an agonist and an antagonist of 5-HT$_{1A}$ serotonin receptors on the behavior of rats tested with a free choice of reinforcement value were studied. Depending on preference for food reinforcement, rats were divided into self-controlled animals (choosing the more valuable but delayed reinforcement) and impulsive (preferring the low-value but immediate reward). One hour before testing, animals received systemic doses of the 5-HT$_{1A}$ receptor agonist 8-OH-DPAT at a dose of 0.1 mg/kg or the selective 5-HT$_{1A}$ antagonist WAY-100635 at a dose of 0.2 mg/kg. Study parameters included the number of presses on one pedal or the other, the latent periods of opening of the screen and pressing on the pedal, and the number of missed screen-moving and pedal-pressing responses. The results of these experiments showed that administration of these agents altered various parameters of the behavior of animals of both groups. Administration of the 5-HT$_{1A}$ agonist 8-OH-DPAT increased the number of pedal-presses to obtain the more valuable reinforcement in impulsive animals, while administration of the 5-HT$_{1A}$ antagonist WAY-100635 had no statistically significant effect on the behavior of the rats.
Starting Page	1068
Ending Page	1075
Page Count	8
File Format	PDF
ISSN	00970549
Journal	Neuroscience and Behavioral Physiology
Volume Number	43
Issue Number	9
e-ISSN	1573899X
Language	English
Publisher	Springer US
Publisher Date	2013-11-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	impulsivity serotonin 8-OH-DPAT WAY-100635 rats Neurosciences Neurobiology Behavioural Sciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
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7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
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9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

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