NDLI: Involvement of Presynaptic 5-HT$_{1A}$ Receptors in Immunomodulation in Conditions of Psychoemotional Tension

Content Provider	Springer Nature Link
Author	Idova, G. V. Davydova, S. M.
Copyright Year	2010
Abstract	The development of an immune reaction in CBA mice during activation and blockade of serotonin 1A (5-HT$_{1A}$) autoreceptors with highly selective agents has characteristic features depending on the behavioral stereotype formed. The 5-HT$_{1A}$ receptor agonist 8-OH-DPAT (0.1 mg/kg 15 min before immunization) did not alter the number of IgM antibody-forming cells in the spleen at the peak of the immune reaction (day 4) in aggressive mice, but increased the number in submissive mice, in which the immune response without treatment was lower than that in aggressive animals. Blockade of the same receptor type with WAY-100635 (0.1 mg/kg 30 min before immunization) led to a decrease in the immune response in animals with aggressive behavior and an increase in submissive animals. The question of the influences of agents acting on presynaptic 5-HT$_{1A}$ somatodendritic autoreceptors on the immune response, depending on the functional state of 5-HT$_{1A}$ receptors and the balance of activities in the serotoninergic and dopaminergic systems as a whole, is discussed.
Starting Page	495
Ending Page	499
Page Count	5
File Format	PDF
ISSN	00970549
Journal	Neuroscience and Behavioral Physiology
Volume Number	40
Issue Number	5
e-ISSN	1573899X
Language	English
Publisher	Springer US
Publisher Date	2010-05-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	immunomodulation psychoemotional state aggression and submission serotoninergic system presynaptic 5-HT$_{1A}$ receptors 8-OH-DPAT WAY-100635 Behavioural Sciences Neurobiology Neurosciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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