NDLI: Effects of Blockade of Dopamine D$_{2}$ Receptors on the Activity of the Nitrergic System of the Nucleus Accumbens in the Rat Brain

Content Provider	Springer Nature Link
Author	Saulskaya, N. B. Sudorgina, P. V.
Copyright Year	2013
Abstract	In vivo intracerebral microdialysis studies with high-performance liquid chromatography and electrochemical detection in Sprague–Dawley rats showed that administration of the dopamine D$_{2}$ receptor antagonist raclopride (20 and 100 μM) into the nucleus accumbens did not alter the baseline extracellular citrulline level (a co-product of NO synthesis) in the nucleus accumbens. Administration of NMDA (100 μM), an NMDA glutamate receptor agonist, into the nucleus accumbens induced an increase in the extracellular citrulline level in this structure. Administration of 7-nitroindazole (0.5 mM), an inhibitor of the neuronal isoform of NO synthase, into the nucleus accumbens blocked this increase, while administration of raclopride (20 and 100 μM) into this structure decreased the increase. These data suggest that dopamine D$_{2}$ receptors in the nucleus accumbens are involved in regulation of the extent of activation of neuronal NO synthase induced by local stimulation of NMDA glutamate receptors.
Starting Page	1023
Ending Page	1027
Page Count	5
File Format	PDF
ISSN	00970549
Journal	Neuroscience and Behavioral Physiology
Volume Number	43
Issue Number	9
e-ISSN	1573899X
Language	English
Publisher	Springer US
Publisher Date	2013-11-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	intracerebral microdialysis nitric oxide nucleus accumbens intertransmitter interactions dopamine D$_{2}$ receptors NMDA receptors Neurosciences Neurobiology Behavioural Sciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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