NDLI: Peripherally Acting Mediators of Pain and Analgesia Potentiate the Central Analgesic Effects of Fentanyl and Analgin (Dipyrone) in Rats

Content Provider	Springer Nature Link
Author	Serdyuk, S. E. Gmiro, V. E.
Copyright Year	2013
Abstract	Intramuscular administration of the central analgesics fentanyl and Analgin (dipyrone) along with the pain mediators cholecystokinin (CCK), glutamate, ATP, and adrenaline, and the analgesia mediator adenosine, which have weak penetration into the CNS, induced maximal analgesic effects at minimally effective doses in the tailflick test in rats. The minimal effective doses of Analgin and fentanyl decreased by factors of 50–220 in response to combined i.m. administration of each of the analgesics with CCK, glutamate, ATP, adrenaline, and adenosine at subthreshold does which were ineffective when given alone. Intragastric administration of lidocaine and subdiaphragmatic gastric vagotomy completely blocked the analgesic effects of these combinations. These data lead to the conclusion that peripherally acting pain and analgesia mediators given systemically potentiate the central analgesic actions of Analgin and fentanyl via stimulation of the chemoreceptors of vagal afferents in the gastric mucosa.
Starting Page	1028
Ending Page	1031
Page Count	4
File Format	PDF
ISSN	00970549
Journal	Neuroscience and Behavioral Physiology
Volume Number	43
Issue Number	9
e-ISSN	1573899X
Language	English
Publisher	Springer US
Publisher Date	2013-11-13
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Mesatone (phenylephrine) adenosine fentanyl Analgin vagus Neurosciences Neurobiology Behavioural Sciences
Content Type	Text
Resource Type	Article
Subject	Neuroscience

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