NDLI: In vitro digestion of curcuminoid-loaded lipid nanoparticles

Content Provider	Springer Nature Link
Author	ack, Andreas Oidtmann, Johannes Kutza, Johannes Mäder, Karsten
Copyright Year	2012
Abstract	Curcuminoid-loaded lipid nanoparticles were produced by melt homogenization. The used lipid matrices were medium chain triglycerides, trimyristin (TM), and tristearin. The mean particle size of the preparations was between 130 and 180 nm. The incorporated curcuminoids revealed a good stability over a period of 12 months. The curcuminoid-loaded lipid nanoparticles were intended for the oral delivery of curcuminoids. Therefore, the fate of the triglyceride matrix in simulated gastric and simulated intestinal media under the influence of pepsin and pancreatin, respectively, was assessed. The degradation of the triglycerides was monitored by the pH–stat method and with high performance thin layer chromatography in connection with spectrodensitometry to quantify the different lipid fractions. The TM nanoparticles were not degraded in simulated gastric fluid (SGF), but the decomposition of the triglyceride matrix was rapid in the intestinal media. The digestion process was faster in the simulated fed state medium compared to the simulated fasted state medium. Additionally, the stability of the incorporated drug was tested in the respective physiological media. The curcuminoids showed an overall good stability in the different test media. The release of the curcuminoids from the lipid nanoparticles was determined by fluorescence imaging techniques. A slow release of the drug was found in phosphate buffer. In contrast, a more distinct release of the curcuminoids was verifiable in SGF and in simulated intestinal fluids. Overall, it was considered that the transfer of the drug into the outer media was mainly triggered by the lipid degradation and not by drug release.
Starting Page	1
Ending Page	19
Page Count	19
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	14
Issue Number	9
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-08-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lipid nanoparticles Curcumin In vitro digestion HPTLC Drug release Drug stability Physical Chemistry Inorganic Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices Characterization and Evaluation of Materials Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

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