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| Content Provider | Springer Nature Link |
|---|---|
| Author | Feng, Runliang Zhu, Wenxia Song, Zhimei Zhao, Liyan Zhai, Guangxi |
| Copyright Year | 2013 |
| Abstract | To improve curcumin’s (CURs) water solubility and release property, a novel star methoxy poly(ethylene glycol)–poly(ε-caprolactone) (MPEG–PCL) copolymer was synthesized through O-alkylation, basic hydrolysis and ring-opening polymerization reaction with MPEG, epichlorohydrin, and ε-caprolactone as raw materials. The structure of the novel copolymer was characterized by $^{1}$H NMR, FT-IR, and GPC. The results of FT-IR and differential scanning calorimeter of CUR-loaded nanoparticles (NPs) prepared by dialysis method showed that CUR was successfully encapsulated into the SMP12 copolymeric NPs with 98.2 % of entrapment efficiency, 10.91 % of drug loading, and 88.4 ± 11.2 nm of mean particle diameter in amorphous forms. The dissolubility of nanoparticulate CUR was increased by 1.38 × 10$^{5}$ times over CUR in water. The obtained blank copolymer showed no hemolysis. A sustained CUR release to a total of approximately 56.13 % was discovered from CUR-NPs in 40 % of ethanol saline solution within 72 h on the use of dialysis method. The release behavior fitted the ambiexponent and biphasic kinetics equation. In conclusion, the copolymeric NPs loading CUR might serve as a potential nanocarrier to improve the solubility and release property of CUR. |
| Starting Page | 1 |
| Ending Page | 12 |
| Page Count | 12 |
| File Format | |
| ISSN | 13880764 |
| Journal | Journal of Nanoparticle Research |
| Volume Number | 15 |
| Issue Number | 6 |
| e-ISSN | 1572896X |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2013-06-02 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Star MPEG–PCL Nanoparticle Curcumin In vitro release Nanotechnology Inorganic Chemistry Characterization and Evaluation of Materials Physical Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation |
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