NDLI: Characterization of nanoparticle-based contrast agents for molecular magnetic resonance imaging

Content Provider	Springer Nature Link
Author	Shan, Liang Chopra, Arvind Leung, Kam Eckelman, William C. Menkens, Anne E.
Copyright Year	2012
Abstract	The development of molecular imaging agents is currently undergoing a dramatic expansion. As of October 2011, ~4,800 newly developed agents have been synthesized and characterized in vitro and in animal models of human disease. Despite this rapid progress, the transfer of these agents to clinical practice is rather slow. To address this issue, the National Institutes of Health launched the Molecular Imaging and Contrast Agents Database (MICAD) in 2005 to provide freely accessible online information regarding molecular imaging probes and contrast agents for the imaging community. While compiling information regarding imaging agents published in peer-reviewed journals, the MICAD editors have observed that some important information regarding the characterization of a contrast agent is not consistently reported. This makes it difficult for investigators to evaluate and meta-analyze data generated from different studies of imaging agents, especially for the agents based on nanoparticles. This article is intended to serve as a guideline for new investigators for the characterization of preclinical studies performed with nanoparticle-based MRI contrast agents. The common characterization parameters are summarized into seven categories: contrast agent designation, physicochemical properties, magnetic properties, in vitro studies, animal studies, MRI studies, and toxicity. Although no single set of parameters is suitable to define the properties of the various types of contrast agents, it is essential to ensure that these agents meet certain quality control parameters at the preclinical stage, so that they can be used without delay for clinical studies.
Starting Page	1
Ending Page	12
Page Count	12
File Format	PDF
ISSN	13880764
Journal	Journal of Nanoparticle Research
Volume Number	14
Issue Number	9
e-ISSN	1572896X
Language	English
Publisher	Springer Netherlands
Publisher Date	2012-08-25
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Contrast agent Nanoparticles Characterization Molecular imaging MRI Physical Chemistry Inorganic Chemistry Optics, Optoelectronics, Plasmonics and Optical Devices Characterization and Evaluation of Materials Nanotechnology
Content Type	Text
Resource Type	Article
Subject	Chemistry Nanoscience and Nanotechnology Atomic and Molecular Physics, and Optics Condensed Matter Physics Bioengineering Modeling and Simulation

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Non-degradable contrast agent with selective phagocytosis for cellular and hepatic magnetic resonance imaging

MRI contrast agent for molecular imaging of the HER2/neu receptor using targeted magnetic nanoparticles

Effect of the hybrid composition on the physicochemical properties and morphology of iron oxide–gold nanoparticles

Paclitaxel-loaded KMnF$_{3}$ nanoparticles for cancer imaging and therapy in vivo

Multifunctional metal ferrite nanoparticles for MR imaging applications

In vivo magnetic resonance and fluorescence dual imaging of tumor sites by using dye-doped silica-coated iron oxide nanoparticles

Preparation and characterization of radiolabeled magnetic nanoparticles as an imaging agent

Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects

Polymeric nanoparticles as OCT contrast agents

Characterization of nanoparticle-based contrast agents for molecular magnetic resonance imaging

Similar Documents

Non-degradable contrast agent with selective phagocytosis for cellular and hepatic magnetic resonance imaging

MRI contrast agent for molecular imaging of the HER2/neu receptor using targeted magnetic nanoparticles

Effect of the hybrid composition on the physicochemical properties and morphology of iron oxide–gold nanoparticles

Paclitaxel-loaded KMnF$_{3}$ nanoparticles for cancer imaging and therapy in vivo

Multifunctional metal ferrite nanoparticles for MR imaging applications

In vivo magnetic resonance and fluorescence dual imaging of tumor sites by using dye-doped silica-coated iron oxide nanoparticles

Preparation and characterization of radiolabeled magnetic nanoparticles as an imaging agent

Ex vivo assessment of polyol coated-iron oxide nanoparticles for MRI diagnosis applications: toxicological and MRI contrast enhancement effects

Polymeric nanoparticles as OCT contrast agents

Characterization of nanoparticle-based contrast agents for molecular magnetic resonance imaging