NDLI: Calcium Channel α$_{2}$δ Subunits: Differential Expression, Function, and Drug Binding

Content Provider	Springer Nature Link
Author	Klugbauer, rbert Marais, Else Hofmann, Franz
Copyright Year	2003
Abstract	Voltage-activated calcium channels are transmembrane proteins that act as transducers of electrical signals into numerous intracellular activities. On the basis of their electrophysiological properties they are classified as high- and low-voltage-activated calcium channels. High-voltage-activated calcium channels are heterooligomeric proteins consisting of a pore-forming α$_{1}$ subunit and auxiliary α$_{2}$δ, β, and—in some tissues—γ subunits. Auxiliary subunits support the membrane trafficking of the α$_{1}$ subunit and modulate the kinetic properties of the channel. In particular, the α$_{2}$δ subunit has been shown to modify the biophysical and pharmacological properties of the α$_{1}$ subunit. The α$_{2}$δ subunit is posttranslationally cleaved to form disulfide-linked α$_{2}$ and, δ proteins, both of which are heavily glycosylated. Recently it was shown that at least four genes encode for α$_{2}$δ subunits which are expressed in a tissue-specific manner. Their biophysical properties were characterized in coexpression studies with high- and low-voltage-activated calcium channels. Mutations in the gene encoding α$_{2}$δ-2 have been found to underlie the ducky phenotype. This mouse mutant is a model for absence epilepsy and is characterized by spike wave seizures and cerebellar ataxia. α$_{2}$δ subunits can also support pharmacological interactions with drugs that are used for the treatment of epilepsy and neuropathic pain.
Starting Page	639
Ending Page	647
Page Count	9
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	35
Issue Number	6
e-ISSN	15736881
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Organic Chemistry Bioorganic Chemistry Biochemistry Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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