NDLI: Differential Expression and Association of Calcium Channel Subunits in Development and Disease

Content Provider	Springer Nature Link
Author	McEnery, Maureen W. Vance, Courtney L. Begg, Catherine M. Lee, Wei Lih Choi, Yunsook Dubel, Stefan J.
Copyright Year	1998
Abstract	Voltage-gated calcium channels (VDCC) are essential to neuronal maturation and differentiation. It is believed that important signaling information is encoded by VDCC-mediated calcium influx that has both spatial and temporal components. VDCC are multimeric complexes comprised of a pore-forming α$_{1}$ subunit and auxiliary β and α$_{2}$/δ subunits. Changes in the fractional contribution of distinct calcium conductances to the total calcium current have been noted in developing and differentiating neurons. These changes are anticipated to reflect the differential expression and localization of the pore-forming α$_{1}$ subunits. However, as in vitro studies have established that β regulates the channel properties and targeting of α$_{1}$, attention has been directed toward the developmental expression and assembly of β isoforms. Recently, changes in the β component of the omega-conotoxin GVIA (CTX)-sensitive N-type VDCC have indicated differential assembly of α$_{1B}$ with β in postnatal rat brain. In addition, unique properties of β4 have been noted with respect to its temporal pattern of expression and incorporation into N-type VDCC complexes. Therefore, the expression and assembly of specific α$_{1}$/β complexes may reflect an elaborate cellular strategy for regulating VDCC diversity. The importance of these developmental findings is bolstered by a recent study which identified mutations in the β4 as the molecular defect in the mutant epileptic mouse (lethargic; lh/lh). As β4 is normally expressed in both forebrain and cerebellum, one may consider the impact of the loss of β4 upon VDCC assembly and activity. The importance of the βlb and β4 isoforms to calcium channel maturation and assembly is discussed.
Starting Page	409
Ending Page	418
Page Count	10
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	30
Issue Number	4
e-ISSN	15736881
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	1998-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Organic Chemistry Bioorganic Chemistry Biochemistry Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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