NDLI: Targeting Mechanisms of High Voltage-Activated Ca$^{2+}$ Channels

Content Provider	Springer Nature Link
Author	Herlitze, Stefan Xie, Mian Han, Jing Hümmer, Alexander Melnik Martinez, Katya V. More, Rosa L. Mark, Melanie D.
Copyright Year	2003
Abstract	Functional voltage-dependent Ca$^{2+}$ channel complexes are assembled by three to four subunits: α$_{1}$, β, α$_{2}$δ subunits (C. Leveque et al., 1994, J. Biol Chem. 269, 6306–6312; M. W. McEnery et al., 1991, Proc. Natl. Acad. Sci. U.S.A. 88, 11095–11099) and at least in muscle cells also γ subunits (B. M. Curtis and W. A. Catterall, 1984, Biochemistry 23, 2113–2118). Ca$^{2+}$ channels mediate the voltage-dependent Ca$^{2+}$ influx in subcellular compartments, triggering such diverse processes as neurotransmitter release, dendritic action potentials, excitation–contraction, and excitation–transcription coupling. The targeting of biophysically defined Ca$^{2+}$ channel complexes to the correct subcellular structures is, thus, critical to proper cell and physiological functioning. Despite their importance, surprisingly little is known about the targeting mechanisms by which Ca$^{2+}$ channel complexes are trausported to their site of function. Here we summarize what we know about the targeting of Ca$^{2+}$ channel complexes through the cell to the plasma membrane and subcellular structures.
Starting Page	621
Ending Page	637
Page Count	17
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	35
Issue Number	6
e-ISSN	15736881
Language	English
Publisher	Kluwer Academic Publishers-Plenum Publishers
Publisher Date	2003-01-01
Publisher Place	New York
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Organic Chemistry Bioorganic Chemistry Biochemistry Animal Biochemistry Animal Anatomy / Morphology / Histology
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
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3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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