NDLI: Effects of ubiquinone derivatives on the mitochondrial unselective channel of Saccharomyces cerevisiae

Content Provider	Springer Nature Link
Author	Gutiérrez Aguilar, Manuel López Carbajal, Helga M. Uribe Alvarez, Cristina Espiza Simón, Emilio Rosas Lemus, Mónica Chiquete Félix, Natalia Uribe Carvajal, Salvador
Copyright Year	2014
Abstract	Ubiquinone derivatives modulate the mammalian mitochondrial Permeability Transition Pore (PTP). Yeast mitochondria harbor a similar structure: the respiration- and ATP-induced Saccharomyces cerevisiae Mitochondrial Unselective Channel ($_{ Sc }$MUC). Here we show that decylubiquinone, a well-characterized inhibitor of the PTP, suppresses $_{ Sc }$MUC opening in diverse strains and independently of respiratory chain modulation or redox-state. We also found that naturally occurring derivatives such as hexaprenyl and decaprenyl ubiquinones lacked effects on the $_{ Sc }$MUC. The PTP-inactive ubiquinone 5 (Ub$_{5}$) promoted the $_{ Sc }$MUC-independent activation of the respiratory chain in most strains tested. In an industrial strain however, Ub$_{5}$ blocked the protection elicited by dUb. The results indicate the presence of a ubiquinone-binding site in the $_{ Sc }$MUC.
Starting Page	519
Ending Page	527
Page Count	9
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	46
Issue Number	6
e-ISSN	15736881
Language	English
Publisher	Springer US
Publisher Date	2014-12-03
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ubiquinone analogues Mitochondria Permeability transition pore Yeast Bioorganic Chemistry Biochemistry Animal Anatomy / Morphology / Histology Animal Biochemistry Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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The Saccharomyces cerevisiae mitochondrial unselective channel behaves as a physiological uncoupling system regulated by Ca$^{2+}$, Mg$^{2+}$, phosphate and ATP

Minireview: Characterization of the Yeast Mitochondria Unselective Channel: A Counterpart to the Mammalian Permeability Transition Pore?

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Effects of ubiquinone derivatives on the mitochondrial unselective channel of Saccharomyces cerevisiae

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The Saccharomyces cerevisiae mitochondrial unselective channel behaves as a physiological uncoupling system regulated by Ca$^{2+}$, Mg$^{2+}$, phosphate and ATP

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