NDLI: Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death

Content Provider	Springer Nature Link
Author	Belliere, Julie Devun, Flavien Cottet Rousselle, Cécile Batandier, Cécile Leverve, Xavier Fontaine, Eric
Copyright Year	2012
Abstract	The permeability transition pore (PTP) is a mitochondrial inner membrane channel involved in cell death. The inhibition of PTP opening has been proved to be an effective strategy to prevent cell death induced by oxidative stress. Several ubiquinone analogs are known to powerfully inhibit PTP opening with an effect depending on the studied cell line. Here, we have studied the effects of ubiquinone 0 (Ub$_{0}$), ubiquinone 5 (Ub$_{5}$) and ubiquinone 10 (Ub$_{10}$) on PTP regulation, H$_{2}$O$_{2}$ production and cell viability in U937 cells. We found that Ub$_{0}$ induced both PTP opening and H$_{2}$O$_{2}$ production. Ub$_{5}$ did not regulate PTP opening yet induced H$_{2}$O$_{2}$ production. Ub$_{10}$ potently inhibited PTP opening yet induced H$_{2}$O$_{2}$ production. Both Ub$_{0}$ and Ub$_{5}$ induced cell death, whereas Ub$_{10}$ was not toxic. Moreover, Ub$_{10}$ prevented tert-butyl hydroperoxide-induced PTP opening and subsequent cell death. We conclude that PTP-inhibitor ubiquinone analogs are able to prevent PTP opening-induced cell death only if they are not toxic per se, which is the case when they have no or low pro-oxidant activity.
Starting Page	207
Ending Page	212
Page Count	6
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	44
Issue Number	1
e-ISSN	15736881
Language	English
Publisher	Springer US
Publisher Date	2012-01-14
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Ubiquinone Permeability transition pore Cell death Mitochondria H$_{2}$O$_{2}$ U937 tert-butyl hydroperoxide Organic Chemistry Animal Anatomy / Morphology / Histology Biochemistry Bioorganic Chemistry Animal Biochemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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Erratum to: Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death

Effects of Decreasing Mitochondrial Volume on the Regulation of the Permeability Transition Pore

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Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death

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Erratum to: Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death

Effects of Decreasing Mitochondrial Volume on the Regulation of the Permeability Transition Pore

Effects of ubiquinone derivatives on the mitochondrial unselective channel of Saccharomyces cerevisiae

Physiological roles of the mitochondrial permeability transition pore

Tl$^{+}$ induces both cationic and transition pore permeability in the inner membrane of rat heart mitochondria

Influence of Tl$^{+}$ on mitochondrial permeability transition pore in Ca$^{2+}$-loaded rat liver mitochondria

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Prerequisites for ubiquinone analogs to prevent mitochondrial permeability transition-induced cell death