NDLI: Tl$^{+}$ induces both cationic and transition pore permeability in the inner membrane of rat heart mitochondria

Content Provider	Springer Nature Link
Author	Korotkov, Sergey M. Nesterov, Vladimir P. Brailovskaya, Irina V. Furaev, Viktor V. vozhilov, Artemy V.
Copyright Year	2013
Abstract	Effects of Tl$^{+}$ were studied in experiments with isolated rat heart mitochondria (RHM) injected into 400 mOsm medium containing TlNO$_{3}$ and a nitrate salt (KNO$_{3}$ or NH$_{4}$NO$_{3}$) or TlNO$_{3}$ and sucrose. Tl$^{+}$ increased permeability of the inner membrane of the RHM to K$^{+}$ and H$^{+}$. This manifested as an increase of the non-energized RHM swelling, in the order of sucrose < K$^{+}$ < NH$_{4}$ $^{+}$, respectively. After succinate administration, the swollen RHM contracted. The Tl$^{+}$-induced opening of the mitochondrial permeability pore (MPTP) in Ca$^{2+}$-loaded rat heart mitochondria increased both the swelling and the inner membrane potential dissipation, as well as decreased basal state and 2,4-dinitrophenol-stimulated respiration. These effects of Tl$^{+}$ were suppressed by the MPTP inhibitors (cyclosporine A, ADP, bongkrekic acid, and n-ethylmaleimide), activated in the presence of the MPTP inducer (carboxyatractyloside) or mitoK$_{ATP}$ inhibitor (5-hydroxydecanoate), but were not altered in the presence of mitoK$_{ATP}$ agonists (diazoxide or pinacidil). We suggest that the greater sensitivity of heart and striated muscles, versus liver, to thallium salts in vivo can result in more vigorous Tl$^{+}$ effects on muscle cell mitochondria.
Starting Page	531
Ending Page	539
Page Count	9
File Format	PDF
ISSN	0145479X
Journal	Journal of Bioenergetics and Biomembranes
Volume Number	45
Issue Number	6
e-ISSN	15736881
Language	English
Publisher	Springer US
Publisher Date	2013-09-22
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tl$^{+}$ Ca$^{2+}$ Mitochondrial permeability transition Mitochondrial bioenergetics Mitochondrial swelling Rat heart mitochondria Bioorganic Chemistry Biochemistry Animal Anatomy / Morphology / Histology Animal Biochemistry Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Cell Biology Physiology

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