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| Content Provider | Springer Nature Link |
|---|---|
| Author | Lahiani Skiba, Malika Coquard, Aude Bouure, Fréderic Vérité, Philippe Arnaud, Philippe Skiba, Mohamed |
| Copyright Year | 2007 |
| Abstract | Mebendazole is an antihelmintic drug, active against many intestinal parasites. Its systemic efficacy is limited by its poor water solubility. The use of natural or derivatized cyclodextrins permeated to multiply notably its apparent solubility, especially with permethyl β-cyclodextrine (PM β-CD) (multiplied by 4700). The inclusion complex formation between mebendazole and this methylated β-cyclodextrin, was characterized by mass spectrometry, powder X-ray diffractometry and Fourier transform infrared spectroscopy: mebendazole seemed to be included in permethyl β-cyclodextrin by its aromatic rings. To prepare inclusion complex of mebendazole and PMβ-CD by solvent evaporation, acetone may be used and the ratio using lower amount of cyclodextrin (MBZ:CD, 1:2) should be used. |
| Starting Page | 197 |
| Ending Page | 201 |
| Page Count | 5 |
| File Format | |
| ISSN | 09230750 |
| Journal | Journal of Inclusion Phenomena and Macrocyclic Chemistry |
| Volume Number | 57 |
| Issue Number | 1-4 |
| e-ISSN | 15731111 |
| Language | English |
| Publisher | Kluwer Academic Publishers |
| Publisher Date | 2007-01-18 |
| Publisher Place | Dordrecht |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Mebendazole Cyclodextrins Inclusion complex Physicochemical characterization Crystallography Food Science Organic Chemistry |
| Content Type | Text |
| Resource Type | Article |
| Subject | Chemistry Condensed Matter Physics Food Science |
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