NDLI: Preparation and characterization of spray dried complexes of lutein with cyclodextrins

Content Provider	Springer Nature Link
Author	Nalawade, Pravin Gajjar, Anuradha
Copyright Year	2015
Abstract	Lutein (LUT) is one of the most important carotenoid and; the most prominent being its antioxidant activity. However, its use is limited due to poor solubility and instability under adverse conditions. An attempt is made to increase the solubility and hence bioavailability of LUT using various cyclodextrins viz., betacyclodextrin (βCD), hydroxypropyl betacyclodextrin (HP-βCD) and methyl betacyclodextrin (M-βCD). Physical mixtures and spray dried inclusion complexes were prepared and characterized using spectroscopic techniques, DSC and XRD studies. From the phase solubility and dissolution studies it was found that, M-βCD significantly improved the solubility of LUT. These complexes were further subjected to in vitro anti-proliferative activity in order to validate results obtained from solubility studies. The biological results were in congruence with the results of solubility studies. Spray dried complex of LUT:M-βCD showed significant percent growth inhibition as compared to other two complexes and LUT alone. Molecular modeling studies established the host–guest stoichiometry with the lowest energy to be 2:1, with the two hexatomic rings of a LUT molecule occupying the two M-βCD cavities. The present study forms the basis for the development of oral formulations of LUT with significantly improved solubility and bioavailability.
Starting Page	77
Ending Page	87
Page Count	11
File Format	PDF
ISSN	13883127
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	83
Issue Number	1-2
e-ISSN	15731111
Language	English
Publisher	Springer Netherlands
Publisher Date	2015-06-20
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lutein Betacyclodextrin Hydroxypropyl betacyclodextrin Methyl betacyclodextrin Inclusion complex Spray drying Organic Chemistry Food Science Crystallography
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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