NDLI: A versatile liposome/cyclodextrin supramolecular carrier for drug delivery through the blood-brain barrier

Content Provider	Springer Nature Link
Author	Machut Binkowski, Cécile Hapiot, Frédéric Cecchelli, Roméo Martin, Patrick Monflier, Eric
Copyright Year	2007
Abstract	For many commercial drugs, reaching the central nervous system in large amount without damaging the blood-brain-barrier (BBB) remains a challenging task. We present here a supramolecular strategy aiming at using a well-defined cyclodextrin-coated liposomes as drug carrier and adamantoyl saccharides as BBB-interacting ligands. In this study, the liposome is constituted of n-alkyldimethylammoniumcyclodextrins incorporated in the lipid bilayer of a 3/7 cholesterol/dipalmitoylphosphatidylcholine mixture and the ligand is constituted of an adamantoylglucose molecule whose adamantoyl moiety can be included in the CD cavity. The whole supramolecular assembly has been characterized by light-scattering and $^{31}$P NMR measurements. Toxicity and permeability studies on an in vitro model of the BBB clearly demonstrated a 5-fold improved ability of the modified liposome to enter the BBB-endothelial cells compared to the non-coated liposome. Fluorescence labelling of these liposomes is also displayed with DiI as a fluorescent probe.
Starting Page	567
Ending Page	572
Page Count	6
File Format	PDF
ISSN	09230750
Journal	Journal of Inclusion Phenomena and Macrocyclic Chemistry
Volume Number	57
Issue Number	1-4
e-ISSN	15731111
Language	English
Publisher	Kluwer Academic Publishers
Publisher Date	2007-01-19
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Blood-brain-barrier Cyclodextrin Drug delivery In vitro model Liposome Saccharide Supramolecular chemistry Crystallography Food Science Organic Chemistry
Content Type	Text
Resource Type	Article
Subject	Chemistry Condensed Matter Physics Food Science

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