NDLI: Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes

Content Provider	Springer Nature Link
Author	Lindor, ralane M. Hopper, John Dowty, James
Copyright Year	2016
Abstract	The rapid clinical embrace of next generation multigene cancer predisposition panels has resulted in discovery of DNA variants in genes for which very limited data on penetrance has been published. Evidence for increased risks associated with these genes is often expressed in odds ratios and studies often were conducted on a priori high risk cohorts, i.e. those with young onset disease and/or positive family histories. Despite these limitations, one can estimate cumulative risks, which may be useful for health care providers who are counselling individuals on their results. We present cumulative risks for several under-studied genes and provide generic information that can be extrapolated to data still emerging.
Starting Page	367
Ending Page	370
Page Count	4
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	15
Issue Number	3
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-03-09
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Penetrance Hazard ratios Odds ratios Hereditary breast cancer Nextgen Cancer panels Cancer Research Human Genetics Epidemiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

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Estimating cumulative risks for breast cancer for carriers of variants in uncommon genes