NDLI: Chemoprevention of familial adenomatous polyposis

Content Provider	Springer Nature Link
Author	Lynch, Patrick M.
Copyright Year	2016
Abstract	Familial adenomatous polyposis (FAP) has always been first and foremost a surgical disease, whose treatment with colectomy has long been known to reduce risk of premature cancer death. The notion of reducing polyp burden and potentially delaying surgical intervention has spawned a host of “chemoprevention” trials. In this paper I selectively review the findings from these studies, highlighting trial design issues and in particular some of the limitations of historical and existing trial endpoint measures. Nonsteroidal anti-inflammatory agents have been the most commonly employed chemopreventive agents. Sulindac, largely by historical accident, has been the most extensively studied, and is widely considered the standard of care when a clinical decision to intervene medically is made. Newer trials are evaluating combinations of agents in order to take advantage of differing mechanisms of action, in the hope of achieving synergy, as no single agent predictably or completely suppresses adenoma growth. Some of these studies and other single-agent interventions are discussed, though an exploration of the various mechanisms of action is beyond the scope of this paper. It is essential that future trials focus on the issue of “clinical benefit”, not simply because the US Food and Drug Administration has insisted on it, but because only real evidence-based advances can improve the standard of medical care for FAP patients. Hence my focus on issues of trial design and clinically relevant endpoints.
Starting Page	467
Ending Page	475
Page Count	9
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	15
Issue Number	3
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-04-15
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Familial adenomatous polyposis (FAP) Nonsteroidal anti-inflammatory agents (NSAIDs) Chemoprevention Cancer Research Human Genetics Epidemiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Gonadal mosaicism and familial adenomatous polyposis

Hepatoblastoma in two siblings and familial adenomatous polyposis: causal nexus or coincidence?

Prospective enteroscopic evaluation of jejunal polyposis in patients with familial adenomatous polyposis and advanced duodenal polyposis

Familial adenomatous polyposis (FAP) and gender. Does gender influence the genetic transmission of FAP?

Familial adenomatous polyposis: not all masses are desmoids

Papillary thyroid cancer in a patient with MUTYH-associated polyposis (MAP)

Rectal cancers in patients with familial adenomatous polyposis

A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Tunisian family with FAP

How harmful is genetic testing for familial adenomatous polyposis (FAP) in young children; the parents’ experience

Chemoprevention of familial adenomatous polyposis

Similar Documents

Gonadal mosaicism and familial adenomatous polyposis

Hepatoblastoma in two siblings and familial adenomatous polyposis: causal nexus or coincidence?

Prospective enteroscopic evaluation of jejunal polyposis in patients with familial adenomatous polyposis and advanced duodenal polyposis

Familial adenomatous polyposis (FAP) and gender. Does gender influence the genetic transmission of FAP?

Familial adenomatous polyposis: not all masses are desmoids

Papillary thyroid cancer in a patient with MUTYH-associated polyposis (MAP)

Rectal cancers in patients with familial adenomatous polyposis

A novel pathogenic germline mutation in the adenomatous polyposis coli gene in a Tunisian family with FAP

How harmful is genetic testing for familial adenomatous polyposis (FAP) in young children; the parents’ experience

Chemoprevention of familial adenomatous polyposis