NDLI: Genetic counseling and cascade genetic testing in Lynch syndrome

Content Provider	Springer Nature Link
Author	Hampel, Heather
Copyright Year	2016
Abstract	Lynch syndrome is the most common cause of inherited colorectal and endometrial cancers. Individuals with Lynch syndrome have a 10–80 % lifetime risk for colorectal cancer and a 15–60 % lifetime risk for endometrial cancer. Both cancers are preventable through chemoprevention, intensive cancer surveillance, and risk-reducing surgery options. Efforts to identify as many individuals with Lynch syndrome as possible will prevent cancers and save lives. This includes the traditional cancer genetic counseling model whereby individuals with and without cancer are evaluated for a possible Lynch syndrome diagnosis based on their personal and family history of colon polyps and cancers. It also includes universal tumor screening for Lynch syndrome whereby all individuals with colorectal or endometrial cancer are screened for tumor features of Lynch syndrome at the time of diagnosis. Those with tumors suspicious for Lynch syndrome are referred for cancer genetic counseling regardless of their family history of cancer. This two approaches must be maximized to attain high patient reach. Finally, and perhaps most importantly, cascade testing among the at-risk relatives of those diagnosed with Lynch syndrome is critically important to maximize the diagnosis of individuals with Lynch syndrome. In fact, the cost-effectiveness of universal tumor screening for Lynch syndrome relies entirely on counseling and testing as many at-risk individuals as possible since young unaffected individuals stand to benefit the most from an early diagnosis of Lynch syndrome. This approach must be optimized to achieve high family reach. It will take a concerted effort from patients, clinicians and public health officials to improve current approaches to the diagnosis of Lynch syndrome and the prevention and treatment of Lynch syndrome-associated cancer but these lessons can be applied to other conditions as the ultimate example of personalized medicine.
Starting Page	423
Ending Page	427
Page Count	5
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	15
Issue Number	3
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2016-03-11
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Lynch syndrome Genetic counseling Cascade testing Genetic testing Cancer Research Human Genetics Epidemiology Biomedicine general
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Attitudes toward childbearing and prenatal testing in individuals undergoing genetic testing for Lynch Syndrome

Lynch syndrome in South America: past, present and future

Genetic testing for Lynch syndrome: family communication and motivation

100 years lynch syndrome: what have we learned about psychosocial issues?

Factors affecting encouragement of relatives among families with Lynch syndrome to seek medical assessment

Fertility and apparent genetic anticipation in Lynch syndrome

Evolution of cancer risk assessment and counseling related to psychological, financial and legal implications

High risk for neoplastic transformation of endometriosis in a carrier of lynch syndrome

Genetic testing for Lynch syndrome in the first year of colorectal cancer: a review of the psychological impact

Genetic counseling and cascade genetic testing in Lynch syndrome

Similar Documents

Attitudes toward childbearing and prenatal testing in individuals undergoing genetic testing for Lynch Syndrome

Lynch syndrome in South America: past, present and future

Genetic testing for Lynch syndrome: family communication and motivation

100 years lynch syndrome: what have we learned about psychosocial issues?

Factors affecting encouragement of relatives among families with Lynch syndrome to seek medical assessment

Fertility and apparent genetic anticipation in Lynch syndrome

Evolution of cancer risk assessment and counseling related to psychological, financial and legal implications

High risk for neoplastic transformation of endometriosis in a carrier of lynch syndrome

Genetic testing for Lynch syndrome in the first year of colorectal cancer: a review of the psychological impact

Genetic counseling and cascade genetic testing in Lynch syndrome