NDLI: Serum levels of IGF-I and BRCA penetrance: a case control study in breast cancer families

Content Provider	Springer Nature Link
Author	Pasanisi, Patrizia Bru, Eleora Venturelli, Elisabetta Maukian, Siraush Barile, Monica Peissel, Bernard Giacomi, Clelia Bonanni, Bernardo Berri, Jacopo Berri, Franco
Copyright Year	2011
Abstract	High serum levels of insulin-like growth factor I (IGF-I) are associated with an increased risk of sporadic breast cancer (BC). The aim of the present work is to evaluate the association between IGF-I and hereditary BC risk, using a case–control approach. The work represents an “ad interim” cross-sectional analysis of an ongoing study with a prospective design whose aim is to recruit a cohort of women belonging to high genetic risk families to test potential modulators of penetrance and prognosis. The odd of exposure to high serum IGF-I levels among women with a previous diagnosis of BC (“cases”) was compared with the odd among unaffected “controls”. The odds ratio (OR) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression, controlling for confounders. We analysed 308 women (209 cases and 99 controls) at high genetic risk of BC. The adjusted OR of BC for the upper tertile of serum IGF-I versus the lowest one was 3.5 (95%CI 1.4–8.8). Excluding from the analysis 64 women under current Tamoxifen or GnRH analogues treatment, the adjusted OR of BC became 3.7 (95%CI 1.4–9.9). The association became stronger restricting the analysis to the 161 women (97 cases and 64 controls) with a proven BRCA mutation. If confirmed by a prospective approach, the association between IGF-I and familial BC will open further options for reducing BC risk in susceptible women.
Starting Page	521
Ending Page	528
Page Count	8
File Format	PDF
ISSN	13899600
Journal	Familial Cancer
Volume Number	10
Issue Number	3
e-ISSN	15737292
Language	English
Publisher	Springer Netherlands
Publisher Date	2011-04-01
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	IGF-I BRCA genes Penetrance Breast cancer prevention Epidemiology Biomedicine general Cancer Research Human Genetics
Content Type	Text
Resource Type	Article
Subject	Genetics Cancer Research Genetics (clinical) Oncology

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