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| Content Provider | Springer Nature Link |
|---|---|
| Author | Hurst, Douglas R. |
| Copyright Year | 2012 |
| Abstract | Epigenetic regulation of gene transcription by histone modification and chromatin remodeling has been linked to many biological and pathological events including cancer metastasis. Breast cancer metastasis suppressor 1 (BRMS1) interacts with SIN3 chromatin remodeling complexes, and, upon forced expression in metastatic cells, a nearly complete suppression of metastasis is noted without preventing primary tumor growth. The data for BRMS1-mediated metastasis suppression and SIN3 interaction are clear; however, connecting the inhibition directly to the association of BRMS1 with SIN3 complexes is currently not well defined. Considering the recent advancements in developing epigenetic drugs for cancer therapy, an improved understanding of how the interactions between BRMS1 and SIN3 regulate the process of metastasis should lead to novel therapies specifically targeting the most deadly aspect of tumor progression. In this article, the data for BRMS1-mediated metastasis suppression are reviewed with a focus on how the SIN3 chromatin remodeling complexes may be functionally involved. |
| Starting Page | 641 |
| Ending Page | 651 |
| Page Count | 11 |
| File Format | |
| ISSN | 01677659 |
| Journal | Cancer and Metastasis Reviews |
| Volume Number | 31 |
| Issue Number | 3-4 |
| e-ISSN | 15737233 |
| Language | English |
| Publisher | Springer US |
| Publisher Date | 2012-06-08 |
| Publisher Place | Boston |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Metastasis suppression Chromatin remodeling BRMS1 SIN3 HDAC Epigenetic Biomedicine general Oncology Cancer Research |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
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