NDLI: The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies

Content Provider	Springer Nature Link
Author	Fokas, Emmauil McKenna, W. Gillies Muschel, Ruth J.
Copyright Year	2012
Abstract	Tumor cells exploit their microenvironment by growth factors and cytokines such as vascular endothelial growth factor (VEGF) to stimulate abnormal vessel formation that is leaky and tortuous, causing irregular blood flow. The combination of poor perfusion, raised interstitial fluid pressure and areas of vascular collapse leads to hypoxia within tumor. The latter activates factors such as hypoxia inducible factor 1 (HIF-1) that serve to make cancer cells more aggressive and also markedly influences the response of malignant tumors to conventional irradiation and chemotherapy. Accumulating data now suggest that blockade of oncogenic signaling, for example by PI3K/Akt/mTOR inhibitors, might consist a promising strategy since these agents do not only possess antitumor effects but can also alter tumor vasculature and oxygenation to improve the response to radiation and chemotherapy. In many cases, these changes are related to downregulation of HIF-1α and VEGF. Here, we review the pathophysiology of tumor microenvironment (TME) and how it adversely affects cancer treatment. The complex interaction of tumor vasculature and radiotherapy is examined together the preclinical evidence supporting a proinvasive/metastatic role for ionising radiation. We will discuss the expanding role of oncogenic signaling, especially PI3K/Akt/mTOR, on tumor angiogenesis. Special emphasis will be paid to the potential of different oncogenic pathways blockade and other indirect antivascular strategies to alter the TME for the benefit of cancer treatment, as an alternative to the classical angiogenetic treatment.
Starting Page	823
Ending Page	842
Page Count	20
File Format	PDF
ISSN	01677659
Journal	Cancer and Metastasis Reviews
Volume Number	31
Issue Number	3-4
e-ISSN	15737233
Language	English
Publisher	Springer US
Publisher Date	2012-07-24
Publisher Place	Boston
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Tumor microenvironment Radiation Angiogenesis Oncogenic signaling Indirect targets Biomedicine general Oncology Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies.

Chemokines in tumor angiogenesis and metastasis

The role of autocrine motility factor in tumor and tumor microenvironment

Tumor dormancy due to failure of angiogenesis: role of the microenvironment

Hedgehog signaling in the murine melanoma microenvironment

Chemotherapy and the tumor microenvironment: the contribution of circulating endothelial cells

Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment

Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94

Stromal cells in tumor microenvironment and breast cancer

The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies

Similar Documents

The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies.

Chemokines in tumor angiogenesis and metastasis

The role of autocrine motility factor in tumor and tumor microenvironment

Tumor dormancy due to failure of angiogenesis: role of the microenvironment

Hedgehog signaling in the murine melanoma microenvironment

Chemotherapy and the tumor microenvironment: the contribution of circulating endothelial cells

Galectin-1 as a potent target for cancer therapy: role in the tumor microenvironment

Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94

Stromal cells in tumor microenvironment and breast cancer

The impact of tumor microenvironment on cancer treatment and its modulation by direct and indirect antivascular strategies