NDLI: Epigenetic contributions to cancer metastasis

Content Provider	Springer Nature Link
Author	Rodenhiser, David I.
Copyright Year	2008
Abstract	The molecular basis of cancer encompasses both genetic and epigenetic alterations. These epigenetic changes primarily involve global DNA methylation changes in the form of widespread loss of methylation along with concurrent hypermethylation events in gene regulatory regions that can repress tissue-specific gene expression. Increasingly, the importance of these epigenetic changes to the metastatic process is being realized. Cells may acquire an epi-genotype that permits their dissemination from the primary tumour mass or the ability to survive and proliferate at a secondary tissue site. These epigenetic changes may be cancer-type specific, or in some cases may involve a common target gene providing a selective advantage to multiple metastatic cell types. In this review, I examine the growing volume of literature related to the epigenetic contributions to cancer metastasis. I discuss the functional importance of these epigenetic phenomena and how new epigenetic biomarkers may permit the identification of diagnostic signatures of metastasis and the development of new cancer therapies.
Starting Page	5
Ending Page	18
Page Count	14
File Format	PDF
ISSN	02620898
Journal	Clinical & Experimental Metastasis
Volume Number	26
Issue Number	1
e-ISSN	15737276
Language	English
Publisher	Springer Netherlands
Publisher Date	2008-04-02
Publisher Place	Dordrecht
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Epigenetic Metastasis Hypermethylation Hypomethylation Surgical Oncology Hematology Oncology Biomedicine general Cancer Research
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Introduction to special issue on ‘epigenetic and physiological regulation of metastasis’

Epigenetic variations in breast cancer progression to lymph node metastasis

Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines

HMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases

Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer

Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer

CCL2 is critical for immunosuppression to promote cancer metastasis

Abstracts the Metastasis Research Society-American Association for Cancer Research Conference on Metastasis

MRS-AACR Joint Conference on Metastasis 2010

Epigenetic contributions to cancer metastasis

Similar Documents

Introduction to special issue on ‘epigenetic and physiological regulation of metastasis’

Epigenetic variations in breast cancer progression to lymph node metastasis

Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines

HMLH1 promoter hypermethylation and MSI status in human endometrial carcinomas with and without metastases

Epigenetic inactivation of galanin and GALR1/2 is associated with early recurrence in head and neck cancer

Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancer

CCL2 is critical for immunosuppression to promote cancer metastasis

Abstracts the Metastasis Research Society-American Association for Cancer Research Conference on Metastasis

MRS-AACR Joint Conference on Metastasis 2010

Epigenetic contributions to cancer metastasis