NDLI: Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium

Content Provider	Springer Nature Link
Author	Bailey, Helen D. Metayer, Catherine Milne, Elizabeth Petridou, Eleni Th. Infante Rivard, Claire Spector, Logan G. Clavel, Jacqueline Dockerty, John D. Zhang, Luoping Armstrong, Bruce K. Rudant, Jérémie Fritschi, Lin Amigou, Alicia Hatzipantelis, Emmanuel Kang, Alice Y. Stiakaki, Eftichia Schüz, Joachim
Copyright Year	2015
Abstract	It has been suggested that home paint exposure increases the risk of childhood acute lymphoblastic leukemia (ALL).We obtained individual level data from eight case–control studies participating in the Childhood Leukemia International Consortium. All studies had home paint exposure data (sometimes including lacquers and varnishes) for the pregnancy period with additional data for the 1–3-month period before conception in five, the year before conception in two, and the period after birth in four studies, respectively. Cytogenetic subtype data were available for some studies. Data were harmonized to a compatible format. Pooled analyses of individual data were undertaken using unconditional logistic regression.Based on 3,002 cases and 3,836 controls, the pooled odds ratio (OR) for home paint exposure in the 1–3 months before conception and risk of ALL was 1.54 [95 % confidence interval (CI) 1.28, 1.85], while based on 1,160 cases and 1,641 controls for exposure in the year before conception, it was 1.00 (95 % CI 0.86, 1.17). For exposure during pregnancy, using 4,382 cases and 5,747 controls, the pooled OR was 1.14 (95 % CI 1.04, 1.25), and for exposure after birth, the OR was 1.22 (95 % CI 1.07, 1.39), based on data from 1,962 cases and 2,973 controls. The risk was greater for certain cytogenetic subtypes and if someone other than the parents did the painting.Home paint exposure shortly before conception, during pregnancy, and/or after birth appeared to increase the risk of childhood ALL. It may be prudent to limit exposure during these periods.
Starting Page	1257
Ending Page	1270
Page Count	14
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	26
Issue Number	9
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2015-07-02
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Paint Acute lymphoblastic leukemia Childhood Pooled analysis Cancer Research Biomedicine general Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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