NDLI: Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis

Content Provider	Springer Nature Link
Author	Karalexi, M. A. Dessypris, N. Skalkidou, A. Biniaris Georgallis, S. I Kalogirou, Ε. Ι. Thomopoulos, T. P. Herlenius, E. Spector, L. G. Loutradis, D. Chrousos, G. P. Petridou, E. Th.
Copyright Year	2017
Abstract	History of fetal loss including miscarriage and stillbirth has been inconsistently associated with childhood (0–14 years) leukemia in subsequent offspring. A quantitative synthesis of the inconclusive literature by leukemia subtype was therefore conducted.Eligible studies (N = 32) were identified through the screening of over 3500 publications. Random-effects meta-analyses were conducted on the association of miscarriage/stillbirth history with overall (AL; 18,868 cases/35,685 controls), acute lymphoblastic (ALL; 16,150 cases/38,655 controls), and myeloid (AML; 3042 cases/32,997 controls) leukemia. Sensitivity and subgroup analyses by age and ALL subtype, as well as meta-regression were undertaken.Fetal loss history was associated with increased AL risk [Odds Ratio (OR) 1.10, 95% Confidence Intervals (CI) 1.04–1.18]. The positive association was seen for ALL (OR 1.12, 95%CI 1.05–1.19) and for AML (OR 1.13, 95%CI 0.91–1.41); for the latter the OR increased in sensitivity analyses. Notably, stillbirth history was significantly linked to ALL risk (OR 1.33, 95%CI 1.02–1.74), but not AML. By contrast, the association of ALL and AML with previous miscarriage reached marginal significance. The association of miscarriage history was strongest in infant ALL (OR 2.34, 95%CI 1.19–4.60).In this meta-analysis involving >50,000 children, we found noteworthy associations by indices of fetal loss, age at diagnosis, and leukemia type; namely, of stillbirth with ALL and miscarriage history with infant ALL. Elucidation of plausible underlying mechanisms may provide insight into leukemia pathogenesis and indicate monitoring interventions prior to and during pregnancy.
Starting Page	599
Ending Page	624
Page Count	26
File Format	PDF
ISSN	09575243
Journal	Cancer Causes & Control
Volume Number	28
Issue Number	6
e-ISSN	15737225
Language	English
Publisher	Springer International Publishing
Publisher Date	2017-04-11
Publisher Place	Cham
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Miscarriage Stillbirth Childhood acute lymphoblastic leukemia Childhood acute myeloid leukemia Meta-analysis Meta-regression Cancer Research Biomedicine Oncology Public Health Epidemiology Hematology
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Maternal Pregnancy Loss, Birth Characteristics, and Childhood Leukemia (United States)

Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium

Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemia

Association betweenMTR A2756Gpolymorphism and childhood acute lymphoblastic leukemia: a meta-analysis

Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia

Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis

Similar Documents

Maternal Pregnancy Loss, Birth Characteristics, and Childhood Leukemia (United States)

Home paint exposures and risk of childhood acute lymphoblastic leukemia: findings from the Childhood Leukemia International Consortium

Fetal growth and body size genes and risk of childhood acute lymphoblastic leukemia

Association betweenMTR A2756Gpolymorphism and childhood acute lymphoblastic leukemia: a meta-analysis

Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

Childhood acute leukemias are frequent in Mexico City: descriptive epidemiology

Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium

Maternal and offspring xenobiotic metabolism haplotypes and the risk of childhood acute lymphoblastic leukemia

Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis